"Nought May Endure but Mutability": Spliceosome Dynamics and the Regulation of Splicing

Duncan J. Smith, Charles C. Query, Maria M. Konarska

Research output: Contribution to journalReview article

120 Scopus citations

Abstract

The spliceosome is both compositionally and conformationally dynamic. Each transition along the splicing pathway presents an opportunity for progression, pausing, or discard, allowing splice site choice to be regulated throughout both the assembly and catalytic phases of the reaction.

Original languageEnglish (US)
Pages (from-to)657-666
Number of pages10
JournalMolecular Cell
Volume30
Issue number6
DOIs
StatePublished - Jun 20 2008

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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