Notch signaling in the nervous system. Pieces still missing from the puzzle

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

Notch has been known for many years as a receptor for inhibitory signals that shapes the pattern of the nervous system during its development. Genes in the Notch pathway function to prevent neural determination so that only a subset of the available ectodermal cells become neural precursors. The localization of Notch signaling is crucial for determining where neural precursor cells arise on a cell-by-cell basis. The unresolved problem is that studies of the expression of Notch protein and its ligands are inconsistent with the pattern of neurogenesis. During neural cell fate specification, distributions of Notch protein and of its ligand Delta appear uniform. Under the reigning paradigm, such widespread expression should lead to N signal transduction in all cells and thereby prevent any neural specification. Yet, contrary to this expectation, neural elements still form, in characteristic patterns, hence, Notch signal transduction must have been inactive in the precursor cells. The mechanism preventing Notch signaling in certain cells must be posttranslational but it has not yet been identified. This review will outline the experimental evidence supporting this view of Notch signaling, and briefly evaluate some of the possible mechanisms that have been suggested. (C) 2000 John Wiley and Sons, Inc.

Original languageEnglish (US)
Pages (from-to)264-273
Number of pages10
JournalBioEssays
Volume22
Issue number3
DOIs
StatePublished - 2000

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Neurology
nervous system
Notch Receptors
Nervous System
Signal transduction
Ligands
Specifications
cells
Genes
signal transduction
Signal Transduction
neurogenesis
Neurogenesis
proteins
neurons
receptors
genes

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Biochemistry
  • Cell Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Agricultural and Biological Sciences (miscellaneous)
  • Plant Science

Cite this

Notch signaling in the nervous system. Pieces still missing from the puzzle. / Baker, Nicholas E.

In: BioEssays, Vol. 22, No. 3, 2000, p. 264-273.

Research output: Contribution to journalArticle

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