Normal range of serum Amphiregulin in healthy adult human females

Esther A. Peterson, Shabana Shabbeer, Paraic A. Kenny

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

ObjectivesPrior to large studies in breast cancer patients, we have sought to establish the normal range of a potential serum biomarker, Amphiregulin, in healthy women and to determine whether sampling during the menstrual cycle influences the detected Amphiregulin levels. Design and methodsSerum Amphiregulin levels were quantified using a commercially available ELISA in 85 normal female donors. ResultsThe range of circulating Amphiregulin was 0-4467. pg/mL. The majority of women had no detectable circulating Amphiregulin (n= 54), and only five women had levels exceeding 500. pg/mL. Serum Amphiregulin levels did not vary significantly during the menstrual cycle (n= 7 women). ConclusionsDetection of circulating Amphiregulin in a significant minority of healthy women suggests that it may not have the specificity necessary for a population screening tool; however its potential utility for monitoring response to treatment or disease progression should be examined in breast cancer cases.

Original languageEnglish (US)
Pages (from-to)460-463
Number of pages4
JournalClinical Biochemistry
Volume45
Issue number6
DOIs
Publication statusPublished - Apr 1 2012

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Keywords

  • Amphiregulin
  • Breast cancer
  • Cytokine
  • Epidermal Growth Factor Receptor
  • Serum biomarker

ASJC Scopus subject areas

  • Clinical Biochemistry

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