Noninvasive assessment of mitral inertance: Clinical results with numerical model validation

M. S. Firstenberg, N. L. Greenberg, N. G. Smedira, P. M. McCarthy, Mario J. Garcia, J. D. Thomas

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

Inertial forces (Mdv/dt) are a significant component of transmitral flow, but cannot be measured with Doppler echo. We validated a method of estimating Mdv/dt. Ten patients had a dual sensor transmitral (TM) catheter placed during cardiac surgery. Doppler and 2D echo was performed while acquiring LA and LV pressures. Mdv/dt was determined from the Bernoulli equation using Doppler velocities and TM gradients. Results were compared with numerical modeling. TM gradients (range: 1.04-14.24 mmHg) consisted of 74.0±11.0% inertial forcers (range: 0.6-12.9 mmHg). Multivariate analysis predicted Mdv/dt=4.171(S/DRATIO) +0.063(LAVOLUME-MAX)+5. Using this equation, a strong relationship was obtained for the clinical dataset (y=0.98x-0.045, r=0.90) and the results of numerical modeling (y=0.96x-0.16, r=0.84). TM gradients are mainly inertial and, as validated by modeling, can be estimated with echocardiography.

Original languageEnglish (US)
Title of host publicationComputers in Cardiology
Pages613-616
Number of pages4
StatePublished - 2001
Externally publishedYes
EventComputer in Cardiology 2001 - Rotterdam, Netherlands
Duration: Sep 23 2001Sep 26 2001

Other

OtherComputer in Cardiology 2001
CountryNetherlands
CityRotterdam
Period9/23/019/26/01

Fingerprint

Echocardiography
Catheters
Surgery
Thoracic Surgery
Numerical models
Multivariate Analysis
Pressure
Sensors
Datasets

ASJC Scopus subject areas

  • Software
  • Cardiology and Cardiovascular Medicine

Cite this

Firstenberg, M. S., Greenberg, N. L., Smedira, N. G., McCarthy, P. M., Garcia, M. J., & Thomas, J. D. (2001). Noninvasive assessment of mitral inertance: Clinical results with numerical model validation. In Computers in Cardiology (pp. 613-616)

Noninvasive assessment of mitral inertance : Clinical results with numerical model validation. / Firstenberg, M. S.; Greenberg, N. L.; Smedira, N. G.; McCarthy, P. M.; Garcia, Mario J.; Thomas, J. D.

Computers in Cardiology. 2001. p. 613-616.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Firstenberg, MS, Greenberg, NL, Smedira, NG, McCarthy, PM, Garcia, MJ & Thomas, JD 2001, Noninvasive assessment of mitral inertance: Clinical results with numerical model validation. in Computers in Cardiology. pp. 613-616, Computer in Cardiology 2001, Rotterdam, Netherlands, 9/23/01.
Firstenberg MS, Greenberg NL, Smedira NG, McCarthy PM, Garcia MJ, Thomas JD. Noninvasive assessment of mitral inertance: Clinical results with numerical model validation. In Computers in Cardiology. 2001. p. 613-616
Firstenberg, M. S. ; Greenberg, N. L. ; Smedira, N. G. ; McCarthy, P. M. ; Garcia, Mario J. ; Thomas, J. D. / Noninvasive assessment of mitral inertance : Clinical results with numerical model validation. Computers in Cardiology. 2001. pp. 613-616
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