Noninvasive assessment of mitral inertance

Clinical results with numerical model validation

M. S. Firstenberg, N. L. Greenberg, N. G. Smedira, P. M. McCarthy, Mario J. Garcia, J. D. Thomas

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

Inertial forces (Mdv/dt) are a significant component of transmitral flow, but cannot be measured with Doppler echo. We validated a method of estimating Mdv/dt. Ten patients had a dual sensor transmitral (TM) catheter placed during cardiac surgery. Doppler and 2D echo was performed while acquiring LA and LV pressures. Mdv/dt was determined from the Bernoulli equation using Doppler velocities and TM gradients. Results were compared with numerical modeling. TM gradients (range: 1.04-14.24 mmHg) consisted of 74.0±11.0% inertial forcers (range: 0.6-12.9 mmHg). Multivariate analysis predicted Mdv/dt=4.171(S/DRATIO) +0.063(LAVOLUME-MAX)+5. Using this equation, a strong relationship was obtained for the clinical dataset (y=0.98x-0.045, r=0.90) and the results of numerical modeling (y=0.96x-0.16, r=0.84). TM gradients are mainly inertial and, as validated by modeling, can be estimated with echocardiography.

Original languageEnglish (US)
Title of host publicationComputers in Cardiology
Pages613-616
Number of pages4
StatePublished - 2001
Externally publishedYes
EventComputer in Cardiology 2001 - Rotterdam, Netherlands
Duration: Sep 23 2001Sep 26 2001

Other

OtherComputer in Cardiology 2001
CountryNetherlands
CityRotterdam
Period9/23/019/26/01

Fingerprint

Echocardiography
Catheters
Surgery
Thoracic Surgery
Numerical models
Multivariate Analysis
Pressure
Sensors
Datasets

ASJC Scopus subject areas

  • Software
  • Cardiology and Cardiovascular Medicine

Cite this

Firstenberg, M. S., Greenberg, N. L., Smedira, N. G., McCarthy, P. M., Garcia, M. J., & Thomas, J. D. (2001). Noninvasive assessment of mitral inertance: Clinical results with numerical model validation. In Computers in Cardiology (pp. 613-616)

Noninvasive assessment of mitral inertance : Clinical results with numerical model validation. / Firstenberg, M. S.; Greenberg, N. L.; Smedira, N. G.; McCarthy, P. M.; Garcia, Mario J.; Thomas, J. D.

Computers in Cardiology. 2001. p. 613-616.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Firstenberg, MS, Greenberg, NL, Smedira, NG, McCarthy, PM, Garcia, MJ & Thomas, JD 2001, Noninvasive assessment of mitral inertance: Clinical results with numerical model validation. in Computers in Cardiology. pp. 613-616, Computer in Cardiology 2001, Rotterdam, Netherlands, 9/23/01.
Firstenberg MS, Greenberg NL, Smedira NG, McCarthy PM, Garcia MJ, Thomas JD. Noninvasive assessment of mitral inertance: Clinical results with numerical model validation. In Computers in Cardiology. 2001. p. 613-616
Firstenberg, M. S. ; Greenberg, N. L. ; Smedira, N. G. ; McCarthy, P. M. ; Garcia, Mario J. ; Thomas, J. D. / Noninvasive assessment of mitral inertance : Clinical results with numerical model validation. Computers in Cardiology. 2001. pp. 613-616
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