Non-coding RNA networks underlying cognitive disorders across the lifespan

Irfan A. Qureshi, Mark F. Mehler

Research output: Contribution to journalReview article

46 Scopus citations

Abstract

Non-coding RNAs (ncRNAs) and their associated regulatory networks are increasingly being implicated in mediating a complex repertoire of neurobiological functions. Cognitive and behavioral processes are proving to be no exception. In this review, we discuss the emergence of many novel, diverse and rapidly expanding classes and subclasses of short and long ncRNAs. We briefly review the life cycles and molecular functions of these ncRNAs. We also examine how ncRNA circuitry mediates brain development, plasticity, stress responses and aging, and highlight its potential roles in the pathophysiology of cognitive disorders, including neural developmental and age-associated neurodegenerative diseases, as well as those that manifest throughout the lifespan.

Original languageEnglish (US)
Pages (from-to)337-346
Number of pages10
JournalTrends in Molecular Medicine
Volume17
Issue number6
DOIs
Publication statusPublished - Jun 1 2011

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ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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