Nocardiosis in tropical renal transplant recipients

George T. John, Viswanathan Shankar, Abi M. Abraham, Mary S. Mathews, Paulose P. Thomas, Chakko K. Jacob

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Background: The epidemiology of nocardiosis in the tropics among renal transplant recipients has not been reported. Methods: An evaluation of nocardiosis for 30 yr in one of the large transplant centres in South Asian region. Results: Of the 1968 patients who received primary renal allografts at Christian Medical College & Hospital, 27 patients developed nocardiosis over 30 yr. Early nocardiosis (≤ 2 yr) was associated with chronic liver disease and the use of cyclosporin (CsA) as compared with its later occurrence (> 2 yr). Seventeen patients (63 %) had two or more associated post-transplant infections, of whom 10 had tuberculosis. Mortality in these patients was associated with chronic liver disease. Conclusions: Nocardiosis manifests earlier (< 2 yr) in CsA treated patients who have chronic liver disease. Among renal transplant recipients of the tropics nocardiosis is a marker of a highsusceptibility to tuberculosis and other infections, the association with tuberculosis is stronger in those developing early nocardiosis (< 2 yr). Chronic liver disease is a risk factor for death in patients with nocardiosis especially when associated with tuberculosis. This report constitutes the largest single centre experience among renal transplant recipients.

Original languageEnglish (US)
Pages (from-to)285-289
Number of pages5
JournalClinical Transplantation
Volume16
Issue number4
DOIs
StatePublished - Jan 1 2002
Externally publishedYes

Keywords

  • Coinfections
  • Nocardiosis
  • Risk factors
  • Tropics

ASJC Scopus subject areas

  • Transplantation

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    John, G. T., Shankar, V., Abraham, A. M., Mathews, M. S., Thomas, P. P., & Jacob, C. K. (2002). Nocardiosis in tropical renal transplant recipients. Clinical Transplantation, 16(4), 285-289. https://doi.org/10.1034/j.1399-0012.2002.01145.x