Nocardiosis in tropical renal transplant recipients

George T. John, Shankar Viswanathan, Abi M. Abraham, Mary S. Mathews, Paulose P. Thomas, Chakko K. Jacob

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: The epidemiology of nocardiosis in the tropics among renal transplant recipients has not been reported. Methods: An evaluation of nocardiosis for 30 yr in one of the large transplant centres in South Asian region. Results: Of the 1968 patients who received primary renal allografts at Christian Medical College & Hospital, 27 patients developed nocardiosis over 30 yr. Early nocardiosis (≤ 2 yr) was associated with chronic liver disease and the use of cyclosporin (CsA) as compared with its later occurrence (> 2 yr). Seventeen patients (63 %) had two or more associated post-transplant infections, of whom 10 had tuberculosis. Mortality in these patients was associated with chronic liver disease. Conclusions: Nocardiosis manifests earlier (< 2 yr) in CsA treated patients who have chronic liver disease. Among renal transplant recipients of the tropics nocardiosis is a marker of a highsusceptibility to tuberculosis and other infections, the association with tuberculosis is stronger in those developing early nocardiosis (< 2 yr). Chronic liver disease is a risk factor for death in patients with nocardiosis especially when associated with tuberculosis. This report constitutes the largest single centre experience among renal transplant recipients.

Original languageEnglish (US)
Pages (from-to)285-289
Number of pages5
JournalClinical Transplantation
Volume16
Issue number4
DOIs
StatePublished - 2002
Externally publishedYes

Fingerprint

Nocardia Infections
Kidney
Liver Diseases
Tuberculosis
Chronic Disease
Transplants
Transplant Recipients
Infection
Cyclosporine
Allografts
Epidemiology
Mortality

Keywords

  • Coinfections
  • Nocardiosis
  • Risk factors
  • Tropics

ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

John, G. T., Viswanathan, S., Abraham, A. M., Mathews, M. S., Thomas, P. P., & Jacob, C. K. (2002). Nocardiosis in tropical renal transplant recipients. Clinical Transplantation, 16(4), 285-289. https://doi.org/10.1034/j.1399-0012.2002.01145.x

Nocardiosis in tropical renal transplant recipients. / John, George T.; Viswanathan, Shankar; Abraham, Abi M.; Mathews, Mary S.; Thomas, Paulose P.; Jacob, Chakko K.

In: Clinical Transplantation, Vol. 16, No. 4, 2002, p. 285-289.

Research output: Contribution to journalArticle

John, GT, Viswanathan, S, Abraham, AM, Mathews, MS, Thomas, PP & Jacob, CK 2002, 'Nocardiosis in tropical renal transplant recipients', Clinical Transplantation, vol. 16, no. 4, pp. 285-289. https://doi.org/10.1034/j.1399-0012.2002.01145.x
John, George T. ; Viswanathan, Shankar ; Abraham, Abi M. ; Mathews, Mary S. ; Thomas, Paulose P. ; Jacob, Chakko K. / Nocardiosis in tropical renal transplant recipients. In: Clinical Transplantation. 2002 ; Vol. 16, No. 4. pp. 285-289.
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