No role for human papillomavirus infection in oral cancers in a region in southern India

Claudie Laprise, Sreenath A. Madathil, Paul Allison, Priya Abraham, Anantharam Raghavendran, Hameed P. Shahul, Akhil Soman Thekkepurakkal, Geneviève Castonguay, François Coutlée, Nicolas F. Schlecht, Marie Claude Rousseau, Eduardo L. Franco, Belinda Nicolau

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Oral cancer is a major public health issue in India with ∼77,000 new cases and 52,000 deaths yearly. Paan chewing, tobacco and alcohol use are strong risk factors for this cancer in India. Human papillomaviruses (HPVs) are also related to a subset of head and neck cancers (HNCs). We examined the association between oral HPV and oral cancer in a sample of Indian subjects participating in a hospital-based case-control study. We recruited incident oral cancer cases (N = 350) and controls frequency-matched by age and sex (N = 371) from two main referral hospitals in Kerala, South India. Sociodemographic and behavioral data were collected by interviews. Epithelial cells were sampled using Oral CDx® brushes from the oral cancer site and the normal mucosa. Detection and genotyping of 36 HPV genotypes were done using a polymerase chain reaction protocol. Data collection procedures were performed by qualified dentists via a detailed protocol with strict quality control, including independent HPV testing in India and Canada. HPV DNA was detected in none of the cases or controls. Associations between oral cancer and risk factors usually associated with HPV infection, such as oral sex and number of lifetime sexual partners, were examined by logistic regression and were not associated with oral cancer. Lack of a role for HPV infection in this study may reflect cultural or religious characteristics specific to this region in India that are not conducive to oral HPV transmission. A nationwide representative prevalence study is needed to investigate HPV prevalence variability among Indian regions. What's new? A new study out of southern India shows that HPV is not the culprit behind the widespread oral cancer in that region. Recently, HPV has been implicated in HNC cases worldwide, and may be responsible for a burgeoning epidemic. Because oral cancer is so prevalent in southern India, the authors wanted to know whether the virus plays a role, especially because an HPV vaccine is available. When they tested for 36 HPV subtypes in oral cancer cases and controls, however, they found no HPV DNA in any of the individuals.

Original languageEnglish (US)
Pages (from-to)912-917
Number of pages6
JournalInternational Journal of Cancer
Volume138
Issue number4
DOIs
StatePublished - Feb 15 2016

Fingerprint

Papillomavirus Infections
Mouth Neoplasms
India
Head and Neck Neoplasms
Smokeless Tobacco
Papillomavirus Vaccines
Sexual Partners
DNA
Tobacco Use
Dentists
Sexual Behavior
Quality Control
Canada
Case-Control Studies
Mucous Membrane
Referral and Consultation
Public Health

Keywords

  • HPV
  • human papillomavirus
  • India
  • oral cancer
  • oral squamous cell carcinoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Laprise, C., Madathil, S. A., Allison, P., Abraham, P., Raghavendran, A., Shahul, H. P., ... Nicolau, B. (2016). No role for human papillomavirus infection in oral cancers in a region in southern India. International Journal of Cancer, 138(4), 912-917. https://doi.org/10.1002/ijc.29827

No role for human papillomavirus infection in oral cancers in a region in southern India. / Laprise, Claudie; Madathil, Sreenath A.; Allison, Paul; Abraham, Priya; Raghavendran, Anantharam; Shahul, Hameed P.; Thekkepurakkal, Akhil Soman; Castonguay, Geneviève; Coutlée, François; Schlecht, Nicolas F.; Rousseau, Marie Claude; Franco, Eduardo L.; Nicolau, Belinda.

In: International Journal of Cancer, Vol. 138, No. 4, 15.02.2016, p. 912-917.

Research output: Contribution to journalArticle

Laprise, C, Madathil, SA, Allison, P, Abraham, P, Raghavendran, A, Shahul, HP, Thekkepurakkal, AS, Castonguay, G, Coutlée, F, Schlecht, NF, Rousseau, MC, Franco, EL & Nicolau, B 2016, 'No role for human papillomavirus infection in oral cancers in a region in southern India', International Journal of Cancer, vol. 138, no. 4, pp. 912-917. https://doi.org/10.1002/ijc.29827
Laprise C, Madathil SA, Allison P, Abraham P, Raghavendran A, Shahul HP et al. No role for human papillomavirus infection in oral cancers in a region in southern India. International Journal of Cancer. 2016 Feb 15;138(4):912-917. https://doi.org/10.1002/ijc.29827
Laprise, Claudie ; Madathil, Sreenath A. ; Allison, Paul ; Abraham, Priya ; Raghavendran, Anantharam ; Shahul, Hameed P. ; Thekkepurakkal, Akhil Soman ; Castonguay, Geneviève ; Coutlée, François ; Schlecht, Nicolas F. ; Rousseau, Marie Claude ; Franco, Eduardo L. ; Nicolau, Belinda. / No role for human papillomavirus infection in oral cancers in a region in southern India. In: International Journal of Cancer. 2016 ; Vol. 138, No. 4. pp. 912-917.
@article{d5ac4d62350e4e12ae16c8b5a1bcb7c8,
title = "No role for human papillomavirus infection in oral cancers in a region in southern India",
abstract = "Oral cancer is a major public health issue in India with ∼77,000 new cases and 52,000 deaths yearly. Paan chewing, tobacco and alcohol use are strong risk factors for this cancer in India. Human papillomaviruses (HPVs) are also related to a subset of head and neck cancers (HNCs). We examined the association between oral HPV and oral cancer in a sample of Indian subjects participating in a hospital-based case-control study. We recruited incident oral cancer cases (N = 350) and controls frequency-matched by age and sex (N = 371) from two main referral hospitals in Kerala, South India. Sociodemographic and behavioral data were collected by interviews. Epithelial cells were sampled using Oral CDx{\circledR} brushes from the oral cancer site and the normal mucosa. Detection and genotyping of 36 HPV genotypes were done using a polymerase chain reaction protocol. Data collection procedures were performed by qualified dentists via a detailed protocol with strict quality control, including independent HPV testing in India and Canada. HPV DNA was detected in none of the cases or controls. Associations between oral cancer and risk factors usually associated with HPV infection, such as oral sex and number of lifetime sexual partners, were examined by logistic regression and were not associated with oral cancer. Lack of a role for HPV infection in this study may reflect cultural or religious characteristics specific to this region in India that are not conducive to oral HPV transmission. A nationwide representative prevalence study is needed to investigate HPV prevalence variability among Indian regions. What's new? A new study out of southern India shows that HPV is not the culprit behind the widespread oral cancer in that region. Recently, HPV has been implicated in HNC cases worldwide, and may be responsible for a burgeoning epidemic. Because oral cancer is so prevalent in southern India, the authors wanted to know whether the virus plays a role, especially because an HPV vaccine is available. When they tested for 36 HPV subtypes in oral cancer cases and controls, however, they found no HPV DNA in any of the individuals.",
keywords = "HPV, human papillomavirus, India, oral cancer, oral squamous cell carcinoma",
author = "Claudie Laprise and Madathil, {Sreenath A.} and Paul Allison and Priya Abraham and Anantharam Raghavendran and Shahul, {Hameed P.} and Thekkepurakkal, {Akhil Soman} and Genevi{\`e}ve Castonguay and Fran{\cc}ois Coutl{\'e}e and Schlecht, {Nicolas F.} and Rousseau, {Marie Claude} and Franco, {Eduardo L.} and Belinda Nicolau",
year = "2016",
month = "2",
day = "15",
doi = "10.1002/ijc.29827",
language = "English (US)",
volume = "138",
pages = "912--917",
journal = "International Journal of Cancer",
issn = "0020-7136",
publisher = "Wiley-Liss Inc.",
number = "4",

}

TY - JOUR

T1 - No role for human papillomavirus infection in oral cancers in a region in southern India

AU - Laprise, Claudie

AU - Madathil, Sreenath A.

AU - Allison, Paul

AU - Abraham, Priya

AU - Raghavendran, Anantharam

AU - Shahul, Hameed P.

AU - Thekkepurakkal, Akhil Soman

AU - Castonguay, Geneviève

AU - Coutlée, François

AU - Schlecht, Nicolas F.

AU - Rousseau, Marie Claude

AU - Franco, Eduardo L.

AU - Nicolau, Belinda

PY - 2016/2/15

Y1 - 2016/2/15

N2 - Oral cancer is a major public health issue in India with ∼77,000 new cases and 52,000 deaths yearly. Paan chewing, tobacco and alcohol use are strong risk factors for this cancer in India. Human papillomaviruses (HPVs) are also related to a subset of head and neck cancers (HNCs). We examined the association between oral HPV and oral cancer in a sample of Indian subjects participating in a hospital-based case-control study. We recruited incident oral cancer cases (N = 350) and controls frequency-matched by age and sex (N = 371) from two main referral hospitals in Kerala, South India. Sociodemographic and behavioral data were collected by interviews. Epithelial cells were sampled using Oral CDx® brushes from the oral cancer site and the normal mucosa. Detection and genotyping of 36 HPV genotypes were done using a polymerase chain reaction protocol. Data collection procedures were performed by qualified dentists via a detailed protocol with strict quality control, including independent HPV testing in India and Canada. HPV DNA was detected in none of the cases or controls. Associations between oral cancer and risk factors usually associated with HPV infection, such as oral sex and number of lifetime sexual partners, were examined by logistic regression and were not associated with oral cancer. Lack of a role for HPV infection in this study may reflect cultural or religious characteristics specific to this region in India that are not conducive to oral HPV transmission. A nationwide representative prevalence study is needed to investigate HPV prevalence variability among Indian regions. What's new? A new study out of southern India shows that HPV is not the culprit behind the widespread oral cancer in that region. Recently, HPV has been implicated in HNC cases worldwide, and may be responsible for a burgeoning epidemic. Because oral cancer is so prevalent in southern India, the authors wanted to know whether the virus plays a role, especially because an HPV vaccine is available. When they tested for 36 HPV subtypes in oral cancer cases and controls, however, they found no HPV DNA in any of the individuals.

AB - Oral cancer is a major public health issue in India with ∼77,000 new cases and 52,000 deaths yearly. Paan chewing, tobacco and alcohol use are strong risk factors for this cancer in India. Human papillomaviruses (HPVs) are also related to a subset of head and neck cancers (HNCs). We examined the association between oral HPV and oral cancer in a sample of Indian subjects participating in a hospital-based case-control study. We recruited incident oral cancer cases (N = 350) and controls frequency-matched by age and sex (N = 371) from two main referral hospitals in Kerala, South India. Sociodemographic and behavioral data were collected by interviews. Epithelial cells were sampled using Oral CDx® brushes from the oral cancer site and the normal mucosa. Detection and genotyping of 36 HPV genotypes were done using a polymerase chain reaction protocol. Data collection procedures were performed by qualified dentists via a detailed protocol with strict quality control, including independent HPV testing in India and Canada. HPV DNA was detected in none of the cases or controls. Associations between oral cancer and risk factors usually associated with HPV infection, such as oral sex and number of lifetime sexual partners, were examined by logistic regression and were not associated with oral cancer. Lack of a role for HPV infection in this study may reflect cultural or religious characteristics specific to this region in India that are not conducive to oral HPV transmission. A nationwide representative prevalence study is needed to investigate HPV prevalence variability among Indian regions. What's new? A new study out of southern India shows that HPV is not the culprit behind the widespread oral cancer in that region. Recently, HPV has been implicated in HNC cases worldwide, and may be responsible for a burgeoning epidemic. Because oral cancer is so prevalent in southern India, the authors wanted to know whether the virus plays a role, especially because an HPV vaccine is available. When they tested for 36 HPV subtypes in oral cancer cases and controls, however, they found no HPV DNA in any of the individuals.

KW - HPV

KW - human papillomavirus

KW - India

KW - oral cancer

KW - oral squamous cell carcinoma

UR - http://www.scopus.com/inward/record.url?scp=84954394380&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84954394380&partnerID=8YFLogxK

U2 - 10.1002/ijc.29827

DO - 10.1002/ijc.29827

M3 - Article

VL - 138

SP - 912

EP - 917

JO - International Journal of Cancer

JF - International Journal of Cancer

SN - 0020-7136

IS - 4

ER -