TY - JOUR
T1 - No role for human papillomavirus infection in oral cancers in a region in southern India
AU - Laprise, Claudie
AU - Madathil, Sreenath A.
AU - Allison, Paul
AU - Abraham, Priya
AU - Raghavendran, Anantharam
AU - Shahul, Hameed P.
AU - Thekkepurakkal, Akhil Soman
AU - Castonguay, Geneviève
AU - Coutlée, François
AU - Schlecht, Nicolas F.
AU - Rousseau, Marie Claude
AU - Franco, Eduardo L.
AU - Nicolau, Belinda
N1 - Publisher Copyright:
© 2015 UICC.
PY - 2016/2/15
Y1 - 2016/2/15
N2 - Oral cancer is a major public health issue in India with ∼77,000 new cases and 52,000 deaths yearly. Paan chewing, tobacco and alcohol use are strong risk factors for this cancer in India. Human papillomaviruses (HPVs) are also related to a subset of head and neck cancers (HNCs). We examined the association between oral HPV and oral cancer in a sample of Indian subjects participating in a hospital-based case-control study. We recruited incident oral cancer cases (N = 350) and controls frequency-matched by age and sex (N = 371) from two main referral hospitals in Kerala, South India. Sociodemographic and behavioral data were collected by interviews. Epithelial cells were sampled using Oral CDx® brushes from the oral cancer site and the normal mucosa. Detection and genotyping of 36 HPV genotypes were done using a polymerase chain reaction protocol. Data collection procedures were performed by qualified dentists via a detailed protocol with strict quality control, including independent HPV testing in India and Canada. HPV DNA was detected in none of the cases or controls. Associations between oral cancer and risk factors usually associated with HPV infection, such as oral sex and number of lifetime sexual partners, were examined by logistic regression and were not associated with oral cancer. Lack of a role for HPV infection in this study may reflect cultural or religious characteristics specific to this region in India that are not conducive to oral HPV transmission. A nationwide representative prevalence study is needed to investigate HPV prevalence variability among Indian regions. What's new? A new study out of southern India shows that HPV is not the culprit behind the widespread oral cancer in that region. Recently, HPV has been implicated in HNC cases worldwide, and may be responsible for a burgeoning epidemic. Because oral cancer is so prevalent in southern India, the authors wanted to know whether the virus plays a role, especially because an HPV vaccine is available. When they tested for 36 HPV subtypes in oral cancer cases and controls, however, they found no HPV DNA in any of the individuals.
AB - Oral cancer is a major public health issue in India with ∼77,000 new cases and 52,000 deaths yearly. Paan chewing, tobacco and alcohol use are strong risk factors for this cancer in India. Human papillomaviruses (HPVs) are also related to a subset of head and neck cancers (HNCs). We examined the association between oral HPV and oral cancer in a sample of Indian subjects participating in a hospital-based case-control study. We recruited incident oral cancer cases (N = 350) and controls frequency-matched by age and sex (N = 371) from two main referral hospitals in Kerala, South India. Sociodemographic and behavioral data were collected by interviews. Epithelial cells were sampled using Oral CDx® brushes from the oral cancer site and the normal mucosa. Detection and genotyping of 36 HPV genotypes were done using a polymerase chain reaction protocol. Data collection procedures were performed by qualified dentists via a detailed protocol with strict quality control, including independent HPV testing in India and Canada. HPV DNA was detected in none of the cases or controls. Associations between oral cancer and risk factors usually associated with HPV infection, such as oral sex and number of lifetime sexual partners, were examined by logistic regression and were not associated with oral cancer. Lack of a role for HPV infection in this study may reflect cultural or religious characteristics specific to this region in India that are not conducive to oral HPV transmission. A nationwide representative prevalence study is needed to investigate HPV prevalence variability among Indian regions. What's new? A new study out of southern India shows that HPV is not the culprit behind the widespread oral cancer in that region. Recently, HPV has been implicated in HNC cases worldwide, and may be responsible for a burgeoning epidemic. Because oral cancer is so prevalent in southern India, the authors wanted to know whether the virus plays a role, especially because an HPV vaccine is available. When they tested for 36 HPV subtypes in oral cancer cases and controls, however, they found no HPV DNA in any of the individuals.
KW - HPV
KW - India
KW - human papillomavirus
KW - oral cancer
KW - oral squamous cell carcinoma
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U2 - 10.1002/ijc.29827
DO - 10.1002/ijc.29827
M3 - Article
C2 - 26317688
AN - SCOPUS:84954394380
SN - 0020-7136
VL - 138
SP - 912
EP - 917
JO - International Journal of Cancer
JF - International Journal of Cancer
IS - 4
ER -