No observable relationship between the ACE gene insertion/deletion polymorphism and psychometric IQ and psychomotor ability in Chinese children

Jianjun Gao, Xiaocai Gao, Wei Qin, Fangli Dang, Fuchang Zhang, Xueqing Qian, Xiaoyang Zeng, Qinghe Xing, Zijian Zheng, Jun Li, Tingwei Guo, Hongfen Chang, Guoyin Feng, Lin He

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The primary aim of this study was to investigate the impact of the angiotensin I-converting enzyme gene (ACE) on general cognitive ability, specific cognitive ability and psychomotor function in Chinese children. In total, 450 children completed both C-WISC tests and ACE I/D genotyping. Of these, 320 children were examined using psychomotor tests. The quantitative traits of psychometric IQ and psychomotor abilities were calculated to determine whether there were any significant differences related to their ACE genotypes on the basis of an analysis of variance. F test results showed no significant differences with regard to any aspect of intelligence or psychomotor performance relative to the various ACE I/D genotypes (all p > 0.05). Our study suggests that ACE I/D do not have a measurable impact on any aspects of IQ or psychomotor ability and that psychomotor ability correlates well with IQ in Chinese children.

Original languageEnglish (US)
Pages (from-to)196-202
Number of pages7
Issue number4
Publication statusPublished - Aug 1 2006



  • Angiotensin I-converting enzyme gene
  • Cognition
  • Intelligence
  • Psychomotor ability

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Psychiatry and Mental health
  • Biological Psychiatry

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