No observable relationship between the ACE gene insertion/deletion polymorphism and psychometric IQ and psychomotor ability in Chinese children

Jianjun Gao; Xiaocai Gao; Wei Qin; Fangli Dang; Fuchang Zhang; Xueqing Qian; Xiaoyang Zeng; Qinghe Xing; Zijian Zheng; Jun Li; Tingwei Guo; Hongfen Chang; Guoyin Feng; Lin He

doi:10.1159/000094728

No observable relationship between the ACE gene insertion/deletion polymorphism and psychometric IQ and psychomotor ability in Chinese children

Jianjun Gao, Xiaocai Gao, Wei Qin, Fangli Dang, Fuchang Zhang, Xueqing Qian, Xiaoyang Zeng, Qinghe Xing, Zijian Zheng, Jun Li, Tingwei Guo, Hongfen Chang, Guoyin Feng, Lin He

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The primary aim of this study was to investigate the impact of the angiotensin I-converting enzyme gene (ACE) on general cognitive ability, specific cognitive ability and psychomotor function in Chinese children. In total, 450 children completed both C-WISC tests and ACE I/D genotyping. Of these, 320 children were examined using psychomotor tests. The quantitative traits of psychometric IQ and psychomotor abilities were calculated to determine whether there were any significant differences related to their ACE genotypes on the basis of an analysis of variance. F test results showed no significant differences with regard to any aspect of intelligence or psychomotor performance relative to the various ACE I/D genotypes (all p > 0.05). Our study suggests that ACE I/D do not have a measurable impact on any aspects of IQ or psychomotor ability and that psychomotor ability correlates well with IQ in Chinese children.

Original language	English (US)
Pages (from-to)	196-202
Number of pages	7
Journal	Neuropsychobiology
Volume	53
Issue number	4
DOIs	https://doi.org/10.1159/000094728
State	Published - Aug 2006
Externally published	Yes

Keywords

Angiotensin I-converting enzyme gene
Cognition
Intelligence
Psychomotor ability

ASJC Scopus subject areas

Neuropsychology and Physiological Psychology
Psychiatry and Mental health
Biological Psychiatry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1159/000094728

Cite this

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title = "No observable relationship between the ACE gene insertion/deletion polymorphism and psychometric IQ and psychomotor ability in Chinese children",

abstract = "The primary aim of this study was to investigate the impact of the angiotensin I-converting enzyme gene (ACE) on general cognitive ability, specific cognitive ability and psychomotor function in Chinese children. In total, 450 children completed both C-WISC tests and ACE I/D genotyping. Of these, 320 children were examined using psychomotor tests. The quantitative traits of psychometric IQ and psychomotor abilities were calculated to determine whether there were any significant differences related to their ACE genotypes on the basis of an analysis of variance. F test results showed no significant differences with regard to any aspect of intelligence or psychomotor performance relative to the various ACE I/D genotypes (all p > 0.05). Our study suggests that ACE I/D do not have a measurable impact on any aspects of IQ or psychomotor ability and that psychomotor ability correlates well with IQ in Chinese children.",

keywords = "Angiotensin I-converting enzyme gene, Cognition, Intelligence, Psychomotor ability",

author = "Jianjun Gao and Xiaocai Gao and Wei Qin and Fangli Dang and Fuchang Zhang and Xueqing Qian and Xiaoyang Zeng and Qinghe Xing and Zijian Zheng and Jun Li and Tingwei Guo and Hongfen Chang and Guoyin Feng and Lin He",

year = "2006",

month = aug,

doi = "10.1159/000094728",

language = "English (US)",

volume = "53",

pages = "196--202",

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T1 - No observable relationship between the ACE gene insertion/deletion polymorphism and psychometric IQ and psychomotor ability in Chinese children

AU - Gao, Jianjun

AU - Gao, Xiaocai

AU - Qin, Wei

AU - Dang, Fangli

AU - Zhang, Fuchang

AU - Qian, Xueqing

AU - Zeng, Xiaoyang

AU - Xing, Qinghe

AU - Zheng, Zijian

AU - Li, Jun

AU - Guo, Tingwei

AU - Chang, Hongfen

AU - Feng, Guoyin

AU - He, Lin

PY - 2006/8

Y1 - 2006/8

N2 - The primary aim of this study was to investigate the impact of the angiotensin I-converting enzyme gene (ACE) on general cognitive ability, specific cognitive ability and psychomotor function in Chinese children. In total, 450 children completed both C-WISC tests and ACE I/D genotyping. Of these, 320 children were examined using psychomotor tests. The quantitative traits of psychometric IQ and psychomotor abilities were calculated to determine whether there were any significant differences related to their ACE genotypes on the basis of an analysis of variance. F test results showed no significant differences with regard to any aspect of intelligence or psychomotor performance relative to the various ACE I/D genotypes (all p > 0.05). Our study suggests that ACE I/D do not have a measurable impact on any aspects of IQ or psychomotor ability and that psychomotor ability correlates well with IQ in Chinese children.

AB - The primary aim of this study was to investigate the impact of the angiotensin I-converting enzyme gene (ACE) on general cognitive ability, specific cognitive ability and psychomotor function in Chinese children. In total, 450 children completed both C-WISC tests and ACE I/D genotyping. Of these, 320 children were examined using psychomotor tests. The quantitative traits of psychometric IQ and psychomotor abilities were calculated to determine whether there were any significant differences related to their ACE genotypes on the basis of an analysis of variance. F test results showed no significant differences with regard to any aspect of intelligence or psychomotor performance relative to the various ACE I/D genotypes (all p > 0.05). Our study suggests that ACE I/D do not have a measurable impact on any aspects of IQ or psychomotor ability and that psychomotor ability correlates well with IQ in Chinese children.

KW - Angiotensin I-converting enzyme gene

KW - Cognition

KW - Intelligence

KW - Psychomotor ability

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No observable relationship between the ACE gene insertion/deletion polymorphism and psychometric IQ and psychomotor ability in Chinese children

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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