No observable relationship between the ACE gene insertion/deletion polymorphism and psychometric IQ and psychomotor ability in Chinese children

Jianjun Gao, Xiaocai Gao, Wei Qin, Fangli Dang, Fuchang Zhang, Xueqing Qian, Xiaoyang Zeng, Qinghe Xing, Zijian Zheng, Jun Li, Tingwei Guo, Hongfen Chang, Guoyin Feng, Lin He

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The primary aim of this study was to investigate the impact of the angiotensin I-converting enzyme gene (ACE) on general cognitive ability, specific cognitive ability and psychomotor function in Chinese children. In total, 450 children completed both C-WISC tests and ACE I/D genotyping. Of these, 320 children were examined using psychomotor tests. The quantitative traits of psychometric IQ and psychomotor abilities were calculated to determine whether there were any significant differences related to their ACE genotypes on the basis of an analysis of variance. F test results showed no significant differences with regard to any aspect of intelligence or psychomotor performance relative to the various ACE I/D genotypes (all p > 0.05). Our study suggests that ACE I/D do not have a measurable impact on any aspects of IQ or psychomotor ability and that psychomotor ability correlates well with IQ in Chinese children.

Original languageEnglish (US)
Pages (from-to)196-202
Number of pages7
JournalNeuropsychobiology
Volume53
Issue number4
DOIs
StatePublished - Aug 2006
Externally publishedYes

Fingerprint

Aptitude
Insertional Mutagenesis
Gene Deletion
Psychometrics
Genotype
Psychomotor Performance
Peptidyl-Dipeptidase A
Intelligence
Analysis of Variance
Genes

Keywords

  • Angiotensin I-converting enzyme gene
  • Cognition
  • Intelligence
  • Psychomotor ability

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuroscience(all)
  • Psychology(all)

Cite this

No observable relationship between the ACE gene insertion/deletion polymorphism and psychometric IQ and psychomotor ability in Chinese children. / Gao, Jianjun; Gao, Xiaocai; Qin, Wei; Dang, Fangli; Zhang, Fuchang; Qian, Xueqing; Zeng, Xiaoyang; Xing, Qinghe; Zheng, Zijian; Li, Jun; Guo, Tingwei; Chang, Hongfen; Feng, Guoyin; He, Lin.

In: Neuropsychobiology, Vol. 53, No. 4, 08.2006, p. 196-202.

Research output: Contribution to journalArticle

Gao, J, Gao, X, Qin, W, Dang, F, Zhang, F, Qian, X, Zeng, X, Xing, Q, Zheng, Z, Li, J, Guo, T, Chang, H, Feng, G & He, L 2006, 'No observable relationship between the ACE gene insertion/deletion polymorphism and psychometric IQ and psychomotor ability in Chinese children', Neuropsychobiology, vol. 53, no. 4, pp. 196-202. https://doi.org/10.1159/000094728
Gao, Jianjun ; Gao, Xiaocai ; Qin, Wei ; Dang, Fangli ; Zhang, Fuchang ; Qian, Xueqing ; Zeng, Xiaoyang ; Xing, Qinghe ; Zheng, Zijian ; Li, Jun ; Guo, Tingwei ; Chang, Hongfen ; Feng, Guoyin ; He, Lin. / No observable relationship between the ACE gene insertion/deletion polymorphism and psychometric IQ and psychomotor ability in Chinese children. In: Neuropsychobiology. 2006 ; Vol. 53, No. 4. pp. 196-202.
@article{133424560caf44e1aa9621e77c923c2f,
title = "No observable relationship between the ACE gene insertion/deletion polymorphism and psychometric IQ and psychomotor ability in Chinese children",
abstract = "The primary aim of this study was to investigate the impact of the angiotensin I-converting enzyme gene (ACE) on general cognitive ability, specific cognitive ability and psychomotor function in Chinese children. In total, 450 children completed both C-WISC tests and ACE I/D genotyping. Of these, 320 children were examined using psychomotor tests. The quantitative traits of psychometric IQ and psychomotor abilities were calculated to determine whether there were any significant differences related to their ACE genotypes on the basis of an analysis of variance. F test results showed no significant differences with regard to any aspect of intelligence or psychomotor performance relative to the various ACE I/D genotypes (all p > 0.05). Our study suggests that ACE I/D do not have a measurable impact on any aspects of IQ or psychomotor ability and that psychomotor ability correlates well with IQ in Chinese children.",
keywords = "Angiotensin I-converting enzyme gene, Cognition, Intelligence, Psychomotor ability",
author = "Jianjun Gao and Xiaocai Gao and Wei Qin and Fangli Dang and Fuchang Zhang and Xueqing Qian and Xiaoyang Zeng and Qinghe Xing and Zijian Zheng and Jun Li and Tingwei Guo and Hongfen Chang and Guoyin Feng and Lin He",
year = "2006",
month = "8",
doi = "10.1159/000094728",
language = "English (US)",
volume = "53",
pages = "196--202",
journal = "Neuropsychobiology",
issn = "0302-282X",
publisher = "S. Karger AG",
number = "4",

}

TY - JOUR

T1 - No observable relationship between the ACE gene insertion/deletion polymorphism and psychometric IQ and psychomotor ability in Chinese children

AU - Gao, Jianjun

AU - Gao, Xiaocai

AU - Qin, Wei

AU - Dang, Fangli

AU - Zhang, Fuchang

AU - Qian, Xueqing

AU - Zeng, Xiaoyang

AU - Xing, Qinghe

AU - Zheng, Zijian

AU - Li, Jun

AU - Guo, Tingwei

AU - Chang, Hongfen

AU - Feng, Guoyin

AU - He, Lin

PY - 2006/8

Y1 - 2006/8

N2 - The primary aim of this study was to investigate the impact of the angiotensin I-converting enzyme gene (ACE) on general cognitive ability, specific cognitive ability and psychomotor function in Chinese children. In total, 450 children completed both C-WISC tests and ACE I/D genotyping. Of these, 320 children were examined using psychomotor tests. The quantitative traits of psychometric IQ and psychomotor abilities were calculated to determine whether there were any significant differences related to their ACE genotypes on the basis of an analysis of variance. F test results showed no significant differences with regard to any aspect of intelligence or psychomotor performance relative to the various ACE I/D genotypes (all p > 0.05). Our study suggests that ACE I/D do not have a measurable impact on any aspects of IQ or psychomotor ability and that psychomotor ability correlates well with IQ in Chinese children.

AB - The primary aim of this study was to investigate the impact of the angiotensin I-converting enzyme gene (ACE) on general cognitive ability, specific cognitive ability and psychomotor function in Chinese children. In total, 450 children completed both C-WISC tests and ACE I/D genotyping. Of these, 320 children were examined using psychomotor tests. The quantitative traits of psychometric IQ and psychomotor abilities were calculated to determine whether there were any significant differences related to their ACE genotypes on the basis of an analysis of variance. F test results showed no significant differences with regard to any aspect of intelligence or psychomotor performance relative to the various ACE I/D genotypes (all p > 0.05). Our study suggests that ACE I/D do not have a measurable impact on any aspects of IQ or psychomotor ability and that psychomotor ability correlates well with IQ in Chinese children.

KW - Angiotensin I-converting enzyme gene

KW - Cognition

KW - Intelligence

KW - Psychomotor ability

UR - http://www.scopus.com/inward/record.url?scp=33747400590&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33747400590&partnerID=8YFLogxK

U2 - 10.1159/000094728

DO - 10.1159/000094728

M3 - Article

C2 - 16874006

AN - SCOPUS:33747400590

VL - 53

SP - 196

EP - 202

JO - Neuropsychobiology

JF - Neuropsychobiology

SN - 0302-282X

IS - 4

ER -