NMR determination that an extended BH3 motif of pro-apoptotic BID is specifically bound to BCL-XL

Hong Ji, Alex Shekhtman, Ranajeet Ghose, James M. McDonnell, David Cowburn

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

The BH3 motif of the pro-survival family of proteins, BCL, is also present in pro-apoptotic proteins like BID and BAX. Homo- and hetero-oligomerization interactions of the BH3 motif are generally recognized as the critical component of their apoptotic activities. In full-length BID, the putative hydrophobic binding surface of its BH3 motif is substantially occluded by intramolecular contacts, many of which are removed on BID's transformation to tBID by cleavage with caspase 8, required for tBID's pro-apoptotic action on mitochondria, thereby releasing cytochrome c.

Original languageEnglish (US)
Pages (from-to)S101-S107
JournalMagnetic Resonance in Chemistry
Volume44
Issue number7 SPEC. ISS.
DOIs
StatePublished - Jul 2006

Keywords

  • Apoptosis
  • BCL-X
  • BH3 motif
  • BID
  • C
  • Death agonist
  • H
  • Helical propensity
  • N
  • NMR

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)

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