Nitric Oxide Releasing Nanoparticle Synthesis and Characterization

George Han, Adam J. Friedman, Joel M. Friedman

Research output: Chapter in Book/Report/Conference proceedingChapter

20 Scopus citations

Abstract

While the potential applications of nitric oxide for both understanding human physiology and treating disease are far reaching, the development of a reliable, cost-effective, and practical sustained delivery system for nitric oxide has yet to emerge. Using a sol–gel/glass hybrid system, we have demonstrated controlled, sustained release of nitric oxide from a stable, dry powder. Upon exposure to an aqueous environment, the material begins releasing therapeutic levels of nitric oxide over several hours to days, making it an ideal material for evaluation of nitric oxide efficacy for both clinical and research applications.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages187-195
Number of pages9
DOIs
StatePublished - 2011

Publication series

NameMethods in Molecular Biology
Volume704
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029

Keywords

  • chitosan
  • nanoparticles
  • Nitric oxide
  • sol–gel
  • sustained release

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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