Nicotinic receptor-mediated effects on appetite and food intake

Young Hwan Jo, David A. Talmage, Lorna W. Role

Research output: Contribution to journalArticlepeer-review

241 Scopus citations


It is well known, although not well understood, that smoking and eating just do not go together. Smoking is associated with decreased food intake and lower body weight. Nicotine, administered either by smoking or by smokeless routes, is considered the major appetite-suppressing component of tobacco. Perhaps the most renowned example of nicotine's influence on appetite and feeding behavior is the significant weight gain associated with smoking cessation. This article presents an overview of the literature at, or near, the interface of nicotinic receptors and appetite regulation. We first consider some of the possible sites of nicotine's action along the complex network of neural and non-neural regulators of feeding. We then present the hypothesis that the lateral hypothalamus is a particularly important locus of the anorectic effects of nicotine. Finally, we discuss the potential role of endogenous cholinergic systems in motivational feeding, focusing on cholinergic pathways in the lateral hypothalamus.

Original languageEnglish (US)
Pages (from-to)618-632
Number of pages15
JournalJournal of Neurobiology
Issue number4
StatePublished - Dec 1 2002
Externally publishedYes


  • Acetylcholine
  • Lateral hypothalamus
  • M-H
  • Orexin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Cellular and Molecular Neuroscience


Dive into the research topics of 'Nicotinic receptor-mediated effects on appetite and food intake'. Together they form a unique fingerprint.

Cite this