Nicardipine reduces calcium accumulation and electrolyte derangements in regional cerebral ischemia in rats

Moshe Hadani, Wise Young, Eugene S. Flamm

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

We studied the effects of the calcium channel blocker nicardipine on regional tissue Ca2+, Na+, K+, and water shifts in the brains of seven Sprague-Dawley rats after permanent occlusions of the middle cerebral artery. We also assessed the entry of [14C]nicardipine into the brains of five rats; the highest concentrations of [14C]nicardipine were in the infarcted area. Nicardipine treatment significantly reduced Ca2+ accumulation in the middle cerebral artery territory by 60% compared with six untreated rats 6 hours after arterial occlusion. Eight 125-μg/kg boluses of nicardipine given every 30 minutes starting 5 minutes after arterial occlusion also significantly reduced the Na+ and K+ shifts in the middle cerebral artery territory by 40% and 50%, respectively, 6 hours after arterial occlusion. Nicardipine appears to reduce Ca2+ accumulation more than it reduces Na+ and water accumulation and K+ loss. Our results suggest that a calcium channel blocker can protect brain tissues in a model of focal cerebral infarction by directly reducing Ca2+ entry into ischemic cells.

Original languageEnglish (US)
Pages (from-to)1125-1132
Number of pages8
JournalStroke
Volume19
Issue number9
DOIs
StatePublished - Sep 1988
Externally publishedYes

Keywords

  • Brain edema
  • Calcium channel blockers
  • Cerebral ischemia
  • Nicardipine
  • Rats

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

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