Nicardipine reduces calcium accumulation and electrolyte derangements in regional cerebral ischemia in rats

Moshe Hadani, Wise Young, Eugene S. Flamm

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

We studied the effects of the calcium channel blocker nicardipine on regional tissue Ca<sup>2+</sup>, Na<sup>+</sup>, K<sup>+</sup>, and water shifts in the brains of seven Sprague-Dawley rats after permanent occlusions of the middle cerebral artery. We also assessed the entry of [<sup>14</sup>C]nicardipine into the brains of five rats; the highest concentrations of [<sup>14</sup>C]nicardipine were in the infarcted area. Nicardipine treatment significantly reduced Ca<sup>2+</sup> accumulation in the middle cerebral artery territory by 60% compared with six untreated rats 6 hours after arterial occlusion. Eight 125-μg/kg boluses of nicardipine given every 30 minutes starting 5 minutes after arterial occlusion also significantly reduced the Na<sup>+</sup> and K<sup>+</sup> shifts in the middle cerebral artery territory by 40% and 50%, respectively, 6 hours after arterial occlusion. Nicardipine appears to reduce Ca<sup>2+</sup> accumulation more than it reduces Na<sup>+</sup> and water accumulation and K<sup>+</sup> loss. Our results suggest that a calcium channel blocker can protect brain tissues in a model of focal cerebral infarction by directly reducing Ca<sup>2+</sup> entry into ischemic cells.

Original languageEnglish (US)
Pages (from-to)1125-1132
Number of pages8
JournalStroke
Volume19
Issue number9
StatePublished - 1988
Externally publishedYes

Fingerprint

Nicardipine
Brain Ischemia
Electrolytes
Calcium
Middle Cerebral Artery
Calcium Channel Blockers
Brain
Water
Middle Cerebral Artery Infarction
Cerebral Infarction
Sprague Dawley Rats

Keywords

  • Brain edema
  • Calcium channel blockers
  • Cerebral ischemia
  • Nicardipine
  • Rats

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialized Nursing
  • Neuroscience(all)

Cite this

Nicardipine reduces calcium accumulation and electrolyte derangements in regional cerebral ischemia in rats. / Hadani, Moshe; Young, Wise; Flamm, Eugene S.

In: Stroke, Vol. 19, No. 9, 1988, p. 1125-1132.

Research output: Contribution to journalArticle

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