New insights on the role of manganese in alzheimer’s disease and parkinson’s disease

Airton Cunha Martins; Patricia Morcillo; Omamuyovwi Meashack Ijomone; Vivek Venkataramani; Fiona Edith Harrison; Eunsook Lee; Aaron Blaine Bowman; Michael Aschner

doi:10.3390/ijerph16193546

New insights on the role of manganese in alzheimer’s disease and parkinson’s disease

Airton Cunha Martins, Patricia Morcillo, Omamuyovwi Meashack Ijomone, Vivek Venkataramani, Fiona Edith Harrison, Eunsook Lee, Aaron Blaine Bowman, Michael Aschner

Molecular Pharmacology

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Manganese (Mn) is an essential trace element that is naturally found in the environment and is necessary as a cofactor for many enzymes and is important in several physiological processes that support development, growth, and neuronal function. However, overexposure to Mn may induce neurotoxicity and may contribute to the development of Alzheimer’s disease (AD) and Parkinson’s disease (PD). The present review aims to provide new insights into the involvement of Mn in the etiology of AD and PD. Here, we discuss the critical role of Mn in the etiology of these disorders and provide a summary of the proposed mechanisms underlying Mn-induced neurodegeneration. In addition, we review some new therapy options for AD and PD related to Mn overload.

Original language	English (US)
Article number	3546
Journal	International journal of environmental research and public health
Volume	16
Issue number	19
DOIs	https://doi.org/10.3390/ijerph16193546
State	Published - Jan 1 2019

Keywords

Alzheimer’s disease
Manganese
Neurodegeneration
Parkinson’s disease

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health
Health, Toxicology and Mutagenesis

Access to Document

10.3390/ijerph16193546

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New insights on the role of manganese in alzheimer’s disease and parkinson’s disease. / Martins, Airton Cunha; Morcillo, Patricia; Ijomone, Omamuyovwi Meashack; Venkataramani, Vivek; Harrison, Fiona Edith; Lee, Eunsook; Bowman, Aaron Blaine; Aschner, Michael.

In: International journal of environmental research and public health, Vol. 16, No. 19, 3546, 01.01.2019.

Research output: Contribution to journal › Article › peer-review

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