New insights on the role of manganese in alzheimer’s disease and parkinson’s disease

Airton Cunha Martins, Patricia Morcillo, Omamuyovwi Meashack Ijomone, Vivek Venkataramani, Fiona Edith Harrison, Eunsook Lee, Aaron Blaine Bowman, Michael Aschner

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Manganese (Mn) is an essential trace element that is naturally found in the environment and is necessary as a cofactor for many enzymes and is important in several physiological processes that support development, growth, and neuronal function. However, overexposure to Mn may induce neurotoxicity and may contribute to the development of Alzheimer’s disease (AD) and Parkinson’s disease (PD). The present review aims to provide new insights into the involvement of Mn in the etiology of AD and PD. Here, we discuss the critical role of Mn in the etiology of these disorders and provide a summary of the proposed mechanisms underlying Mn-induced neurodegeneration. In addition, we review some new therapy options for AD and PD related to Mn overload.

Original languageEnglish (US)
Article number3546
JournalInternational journal of environmental research and public health
Volume16
Issue number19
DOIs
StatePublished - Jan 1 2019

Keywords

  • Alzheimer’s disease
  • Manganese
  • Neurodegeneration
  • Parkinson’s disease

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

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