TY - JOUR
T1 - New insights on the role of manganese in alzheimer’s disease and parkinson’s disease
AU - Martins, Airton Cunha
AU - Morcillo, Patricia
AU - Ijomone, Omamuyovwi Meashack
AU - Venkataramani, Vivek
AU - Harrison, Fiona Edith
AU - Lee, Eunsook
AU - Bowman, Aaron Blaine
AU - Aschner, Michael
N1 - Funding Information:
Funding: This research was funded by National Institutes of Health [NIH] and Veterans Affairs [VA] grants: NIH/NIEHS RO1 ES010563 [ABB and MA], NIH/NIEHS R01 ES024756 [EL], NIH/NIEHS RO1 ES016931-12S1 [ABB, FEH, MA], and I01 CX001610-01 [FEH].
PY - 2019
Y1 - 2019
N2 - Manganese (Mn) is an essential trace element that is naturally found in the environment and is necessary as a cofactor for many enzymes and is important in several physiological processes that support development, growth, and neuronal function. However, overexposure to Mn may induce neurotoxicity and may contribute to the development of Alzheimer’s disease (AD) and Parkinson’s disease (PD). The present review aims to provide new insights into the involvement of Mn in the etiology of AD and PD. Here, we discuss the critical role of Mn in the etiology of these disorders and provide a summary of the proposed mechanisms underlying Mn-induced neurodegeneration. In addition, we review some new therapy options for AD and PD related to Mn overload.
AB - Manganese (Mn) is an essential trace element that is naturally found in the environment and is necessary as a cofactor for many enzymes and is important in several physiological processes that support development, growth, and neuronal function. However, overexposure to Mn may induce neurotoxicity and may contribute to the development of Alzheimer’s disease (AD) and Parkinson’s disease (PD). The present review aims to provide new insights into the involvement of Mn in the etiology of AD and PD. Here, we discuss the critical role of Mn in the etiology of these disorders and provide a summary of the proposed mechanisms underlying Mn-induced neurodegeneration. In addition, we review some new therapy options for AD and PD related to Mn overload.
KW - Alzheimer’s disease
KW - Manganese
KW - Neurodegeneration
KW - Parkinson’s disease
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U2 - 10.3390/ijerph16193546
DO - 10.3390/ijerph16193546
M3 - Article
C2 - 31546716
AN - SCOPUS:85072566012
VL - 16
JO - International Journal of Environmental Research and Public Health
JF - International Journal of Environmental Research and Public Health
SN - 1661-7827
IS - 19
M1 - 3546
ER -