Abstract
Manganese (Mn) is an essential trace element that is naturally found in the environment and is necessary as a cofactor for many enzymes and is important in several physiological processes that support development, growth, and neuronal function. However, overexposure to Mn may induce neurotoxicity and may contribute to the development of Alzheimer’s disease (AD) and Parkinson’s disease (PD). The present review aims to provide new insights into the involvement of Mn in the etiology of AD and PD. Here, we discuss the critical role of Mn in the etiology of these disorders and provide a summary of the proposed mechanisms underlying Mn-induced neurodegeneration. In addition, we review some new therapy options for AD and PD related to Mn overload.
| Original language | English (US) |
|---|---|
| Article number | 3546 |
| Journal | International journal of environmental research and public health |
| Volume | 16 |
| Issue number | 19 |
| DOIs | |
| State | Published - Jan 1 2019 |
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Keywords
- Alzheimer’s disease
- Manganese
- Neurodegeneration
- Parkinson’s disease
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
- Health, Toxicology and Mutagenesis
Cite this
New insights on the role of manganese in alzheimer’s disease and parkinson’s disease. / Martins, Airton Cunha; Morcillo, Patricia; Ijomone, Omamuyovwi Meashack; Venkataramani, Vivek; Harrison, Fiona Edith; Lee, Eunsook; Bowman, Aaron Blaine; Aschner, Michael.
In: International journal of environmental research and public health, Vol. 16, No. 19, 3546, 01.01.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - New insights on the role of manganese in alzheimer’s disease and parkinson’s disease
AU - Martins, Airton Cunha
AU - Morcillo, Patricia
AU - Ijomone, Omamuyovwi Meashack
AU - Venkataramani, Vivek
AU - Harrison, Fiona Edith
AU - Lee, Eunsook
AU - Bowman, Aaron Blaine
AU - Aschner, Michael
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Manganese (Mn) is an essential trace element that is naturally found in the environment and is necessary as a cofactor for many enzymes and is important in several physiological processes that support development, growth, and neuronal function. However, overexposure to Mn may induce neurotoxicity and may contribute to the development of Alzheimer’s disease (AD) and Parkinson’s disease (PD). The present review aims to provide new insights into the involvement of Mn in the etiology of AD and PD. Here, we discuss the critical role of Mn in the etiology of these disorders and provide a summary of the proposed mechanisms underlying Mn-induced neurodegeneration. In addition, we review some new therapy options for AD and PD related to Mn overload.
AB - Manganese (Mn) is an essential trace element that is naturally found in the environment and is necessary as a cofactor for many enzymes and is important in several physiological processes that support development, growth, and neuronal function. However, overexposure to Mn may induce neurotoxicity and may contribute to the development of Alzheimer’s disease (AD) and Parkinson’s disease (PD). The present review aims to provide new insights into the involvement of Mn in the etiology of AD and PD. Here, we discuss the critical role of Mn in the etiology of these disorders and provide a summary of the proposed mechanisms underlying Mn-induced neurodegeneration. In addition, we review some new therapy options for AD and PD related to Mn overload.
KW - Alzheimer’s disease
KW - Manganese
KW - Neurodegeneration
KW - Parkinson’s disease
UR - http://www.scopus.com/inward/record.url?scp=85072566012&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85072566012&partnerID=8YFLogxK
U2 - 10.3390/ijerph16193546
DO - 10.3390/ijerph16193546
M3 - Article
C2 - 31546716
AN - SCOPUS:85072566012
VL - 16
JO - International Journal of Environmental Research and Public Health
JF - International Journal of Environmental Research and Public Health
SN - 1661-7827
IS - 19
M1 - 3546
ER -