New clues to understanding HIV nonprogressors: Low cholesterol blocks HIV trans infection

Vinayaka R. Prasad, Michael I. Bukrinsky

Research output: Contribution to journalArticle

6 Scopus citations


A small percentage of HIV-infected subjects (2 to 15%) are able to control disease progression for many years without antiretroviral therapy. Years of intense studies of virologic and immunologic mechanisms of disease control in such individuals yielded a number of possible host genes that could be responsible for the preservation of immune functions, from immune surveillance genes, chemokines, or their receptors to anti-HIV restriction factors. A recent mBio paper by Rappocciolo et al. (G. Rappocciolo, M. Jais, P. Piazza, T. A. Reinhart, S. J. Berendam, L. Garcia-Exposito, P. Gupta, and C. R. Rinaldo, mBio 5:e01031- 13, 2014) describes another potential factor controlling disease progression: Cholesterol levels in antigen-presenting cells. In this commentary, we provide a brief background of the role of cholesterol in HIV infection, discuss the results of the study by Rappocciolo et al., and present the implications of their findings.

Original languageEnglish (US)
Issue number3
Publication statusPublished - Jun 10 2014


ASJC Scopus subject areas

  • Microbiology
  • Virology

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