Neutrophils, platelets, and inflammatory pathways at the nexus of sickle cell disease pathophysiology

Research output: Contribution to journalReview article

154 Scopus citations

Abstract

Sickle cell disease (SCD) is a severe genetic blood disorder characterized by hemolytic anemia, episodic vaso-occlusion, and progressive organ damage. Current management of the disease remains symptomatic or preventative. Specific treatment targeting major complications such as vasoocclusion is still lacking. Recent studies have identified various cellular and molecular factors that contribute to the pathophysiology of SCD. Here, we review the role of these elements and discuss the opportunities for therapeutic intervention.

Original languageEnglish (US)
Pages (from-to)801-809
Number of pages9
JournalBlood
Volume127
Issue number7
DOIs
StatePublished - Feb 18 2016

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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