Neutrophils, platelets, and inflammatory pathways at the nexus of sickle cell disease pathophysiology

Dachuan Zhang, Chunliang Xu, Deepa G. Manwani, Paul S. Frenette

Research output: Contribution to journalArticle

114 Citations (Scopus)

Abstract

Sickle cell disease (SCD) is a severe genetic blood disorder characterized by hemolytic anemia, episodic vaso-occlusion, and progressive organ damage. Current management of the disease remains symptomatic or preventative. Specific treatment targeting major complications such as vasoocclusion is still lacking. Recent studies have identified various cellular and molecular factors that contribute to the pathophysiology of SCD. Here, we review the role of these elements and discuss the opportunities for therapeutic intervention.

Original languageEnglish (US)
Pages (from-to)801-809
Number of pages9
JournalBlood
Volume127
Issue number7
DOIs
StatePublished - Feb 18 2016

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Sickle Cell Anemia
Platelets
Neutrophils
Blood Platelets
Inborn Genetic Diseases
Hemolytic Anemia
Disease Management
Blood
Nexus
Therapeutics

ASJC Scopus subject areas

  • Hematology
  • Biochemistry
  • Cell Biology
  • Immunology

Cite this

Neutrophils, platelets, and inflammatory pathways at the nexus of sickle cell disease pathophysiology. / Zhang, Dachuan; Xu, Chunliang; Manwani, Deepa G.; Frenette, Paul S.

In: Blood, Vol. 127, No. 7, 18.02.2016, p. 801-809.

Research output: Contribution to journalArticle

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