Neutrophil microdomains

Linking heterocellular interactions with vascular injury

Christoph Scheiermann, Yuya Kunisaki, Jung Eun Jang, Paul S. Frenette

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Purpose of review: Neutrophil infiltration is an important feature in inflammatory scenarios. Before these cells infiltrate tissues, however, they contribute to crucial intravascular events in which neutrophil microdomains mediate heterotypic interactions with endothelial cells, red blood cells and/or platelets. In vascular diseases, this can result in exacerbated neutrophil activation, subsequent vascular injury and obstruction of microcirculatory blood flow. This review discusses recent advances in elucidating these neutrophil domains and their associated functions in cell adhesion. Recent findings: Neutrophil recruitment is mediated by sequential interactions with the endothelium, termed rolling, adhesion and extravasation. Evidence points to novel signaling pathways induced during the rolling phase resulting in the transition to leukocyte adhesion, which appear to contribute to chemokine mediated activation. In addition, specific neutrophil microdomains are important for interactions with other hematopoietic cells inducing reductions in microvascular flow and injury. Summary: Neutrophils integrate signals received from the endothelium to act as linkers between the vessel wall and a variety of vascular components (i.e. endothelial cells, platelets, red blood cells) in acute and chronic inflammatory conditions to mediate interactions that can result in vascular injury and vasoocclusion.

Original languageEnglish (US)
Pages (from-to)25-30
Number of pages6
JournalCurrent Opinion in Hematology
Volume17
Issue number1
DOIs
StatePublished - Jan 2010
Externally publishedYes

Fingerprint

Vascular System Injuries
Neutrophils
Neutrophil Infiltration
Endothelium
Blood Platelets
Endothelial Cells
Erythrocytes
Neutrophil Activation
Vascular Diseases
Chemokines
Cell Adhesion
Blood Vessels
Leukocytes
Wounds and Injuries

Keywords

  • Heterotypic interactions
  • Neutrophil adhesion
  • Polarization
  • Signaling

ASJC Scopus subject areas

  • Hematology

Cite this

Neutrophil microdomains : Linking heterocellular interactions with vascular injury. / Scheiermann, Christoph; Kunisaki, Yuya; Jang, Jung Eun; Frenette, Paul S.

In: Current Opinion in Hematology, Vol. 17, No. 1, 01.2010, p. 25-30.

Research output: Contribution to journalArticle

Scheiermann, Christoph ; Kunisaki, Yuya ; Jang, Jung Eun ; Frenette, Paul S. / Neutrophil microdomains : Linking heterocellular interactions with vascular injury. In: Current Opinion in Hematology. 2010 ; Vol. 17, No. 1. pp. 25-30.
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