Neurophysiological markers of alert responding during goal-directed behavior: A high-density electrical mapping study

Paul M. Dockree, Simon P. Kelly, Ian H. Robertson, Richard B. Reilly, John J. Foxe

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

The ability to dynamically modulate the intensity of sustained attention (i.e., alertness) is an essential component of the human executive control system, allowing us to function purposefully in accordance with our goals. In this study we examine high-density ERP markers of alert responding during the fixed sequence sustained attention to response task (SARTfixed). This paradigm has proven to be a sensitive clinical metric in patient populations with deficits in their ability to sustain attention (e.g., attention deficit hyperactivity disorder). In this task subjects withhold a button press to an infrequent no-go target ('3') embedded within a predictable sequence of numbers ('1' to '9'). Our data reveal a complex pattern of effects across the trial sequence of the SART, with clear contributions from frontal and parietal cortices to sustained attentional performance. Over occipito-parietal regions, early visual attention processes were increased during trial 2 (i.e., trial in which the digit '2' was presented) and trial 3, giving rise to the so-called selection negativity (SN). Two prominent late components were manifest during trial 2: LP1 (550-800 ms) and LP2 (850-1150 ms) over occipito-parietal and central sites. We interpret the LP1 component on trial 2 as reflecting retrieval of the task goal and the subsequent LP2 as reflecting competition between the currently relevant go response and the subsequent no-go response. On trial 3, an enhanced "no-go N2" (250-450 ms) was seen fronto-centrally in the absence of the "no-go P3" that typically follows. Fronto-polar activity was also seen across all trials and may be indicative of subgoal processes to integrate the association between stimulus and goal. Prior to a lapse of attention (i.e., failure to inhibit a response to "3") the LP1 was significantly attenuated on the preceding trial 2 indicating a failure of anticipatory goal-directed processing. The results are discussed in terms of models of sustained attention involving frontal and parietal cortices.

Original languageEnglish (US)
Pages (from-to)587-601
Number of pages15
JournalNeuroImage
Volume27
Issue number3
DOIs
StatePublished - Sep 2005
Externally publishedYes

Fingerprint

Parietal Lobe
Aptitude
Frontal Lobe
Executive Function
Attention Deficit Disorder with Hyperactivity
Population

Keywords

  • Delayed intentions
  • Early visual attention
  • Go/no-go task
  • Goal-directed behavior
  • High-density ERPs
  • Lapses of attention
  • Selection negativity
  • Sustained attention

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Neurology

Cite this

Neurophysiological markers of alert responding during goal-directed behavior : A high-density electrical mapping study. / Dockree, Paul M.; Kelly, Simon P.; Robertson, Ian H.; Reilly, Richard B.; Foxe, John J.

In: NeuroImage, Vol. 27, No. 3, 09.2005, p. 587-601.

Research output: Contribution to journalArticle

Dockree, Paul M. ; Kelly, Simon P. ; Robertson, Ian H. ; Reilly, Richard B. ; Foxe, John J. / Neurophysiological markers of alert responding during goal-directed behavior : A high-density electrical mapping study. In: NeuroImage. 2005 ; Vol. 27, No. 3. pp. 587-601.
@article{cf5a300d49ac460cb6353808c7d8202f,
title = "Neurophysiological markers of alert responding during goal-directed behavior: A high-density electrical mapping study",
abstract = "The ability to dynamically modulate the intensity of sustained attention (i.e., alertness) is an essential component of the human executive control system, allowing us to function purposefully in accordance with our goals. In this study we examine high-density ERP markers of alert responding during the fixed sequence sustained attention to response task (SARTfixed). This paradigm has proven to be a sensitive clinical metric in patient populations with deficits in their ability to sustain attention (e.g., attention deficit hyperactivity disorder). In this task subjects withhold a button press to an infrequent no-go target ('3') embedded within a predictable sequence of numbers ('1' to '9'). Our data reveal a complex pattern of effects across the trial sequence of the SART, with clear contributions from frontal and parietal cortices to sustained attentional performance. Over occipito-parietal regions, early visual attention processes were increased during trial 2 (i.e., trial in which the digit '2' was presented) and trial 3, giving rise to the so-called selection negativity (SN). Two prominent late components were manifest during trial 2: LP1 (550-800 ms) and LP2 (850-1150 ms) over occipito-parietal and central sites. We interpret the LP1 component on trial 2 as reflecting retrieval of the task goal and the subsequent LP2 as reflecting competition between the currently relevant go response and the subsequent no-go response. On trial 3, an enhanced {"}no-go N2{"} (250-450 ms) was seen fronto-centrally in the absence of the {"}no-go P3{"} that typically follows. Fronto-polar activity was also seen across all trials and may be indicative of subgoal processes to integrate the association between stimulus and goal. Prior to a lapse of attention (i.e., failure to inhibit a response to {"}3{"}) the LP1 was significantly attenuated on the preceding trial 2 indicating a failure of anticipatory goal-directed processing. The results are discussed in terms of models of sustained attention involving frontal and parietal cortices.",
keywords = "Delayed intentions, Early visual attention, Go/no-go task, Goal-directed behavior, High-density ERPs, Lapses of attention, Selection negativity, Sustained attention",
author = "Dockree, {Paul M.} and Kelly, {Simon P.} and Robertson, {Ian H.} and Reilly, {Richard B.} and Foxe, {John J.}",
year = "2005",
month = "9",
doi = "10.1016/j.neuroimage.2005.05.044",
language = "English (US)",
volume = "27",
pages = "587--601",
journal = "NeuroImage",
issn = "1053-8119",
publisher = "Academic Press Inc.",
number = "3",

}

TY - JOUR

T1 - Neurophysiological markers of alert responding during goal-directed behavior

T2 - A high-density electrical mapping study

AU - Dockree, Paul M.

AU - Kelly, Simon P.

AU - Robertson, Ian H.

AU - Reilly, Richard B.

AU - Foxe, John J.

PY - 2005/9

Y1 - 2005/9

N2 - The ability to dynamically modulate the intensity of sustained attention (i.e., alertness) is an essential component of the human executive control system, allowing us to function purposefully in accordance with our goals. In this study we examine high-density ERP markers of alert responding during the fixed sequence sustained attention to response task (SARTfixed). This paradigm has proven to be a sensitive clinical metric in patient populations with deficits in their ability to sustain attention (e.g., attention deficit hyperactivity disorder). In this task subjects withhold a button press to an infrequent no-go target ('3') embedded within a predictable sequence of numbers ('1' to '9'). Our data reveal a complex pattern of effects across the trial sequence of the SART, with clear contributions from frontal and parietal cortices to sustained attentional performance. Over occipito-parietal regions, early visual attention processes were increased during trial 2 (i.e., trial in which the digit '2' was presented) and trial 3, giving rise to the so-called selection negativity (SN). Two prominent late components were manifest during trial 2: LP1 (550-800 ms) and LP2 (850-1150 ms) over occipito-parietal and central sites. We interpret the LP1 component on trial 2 as reflecting retrieval of the task goal and the subsequent LP2 as reflecting competition between the currently relevant go response and the subsequent no-go response. On trial 3, an enhanced "no-go N2" (250-450 ms) was seen fronto-centrally in the absence of the "no-go P3" that typically follows. Fronto-polar activity was also seen across all trials and may be indicative of subgoal processes to integrate the association between stimulus and goal. Prior to a lapse of attention (i.e., failure to inhibit a response to "3") the LP1 was significantly attenuated on the preceding trial 2 indicating a failure of anticipatory goal-directed processing. The results are discussed in terms of models of sustained attention involving frontal and parietal cortices.

AB - The ability to dynamically modulate the intensity of sustained attention (i.e., alertness) is an essential component of the human executive control system, allowing us to function purposefully in accordance with our goals. In this study we examine high-density ERP markers of alert responding during the fixed sequence sustained attention to response task (SARTfixed). This paradigm has proven to be a sensitive clinical metric in patient populations with deficits in their ability to sustain attention (e.g., attention deficit hyperactivity disorder). In this task subjects withhold a button press to an infrequent no-go target ('3') embedded within a predictable sequence of numbers ('1' to '9'). Our data reveal a complex pattern of effects across the trial sequence of the SART, with clear contributions from frontal and parietal cortices to sustained attentional performance. Over occipito-parietal regions, early visual attention processes were increased during trial 2 (i.e., trial in which the digit '2' was presented) and trial 3, giving rise to the so-called selection negativity (SN). Two prominent late components were manifest during trial 2: LP1 (550-800 ms) and LP2 (850-1150 ms) over occipito-parietal and central sites. We interpret the LP1 component on trial 2 as reflecting retrieval of the task goal and the subsequent LP2 as reflecting competition between the currently relevant go response and the subsequent no-go response. On trial 3, an enhanced "no-go N2" (250-450 ms) was seen fronto-centrally in the absence of the "no-go P3" that typically follows. Fronto-polar activity was also seen across all trials and may be indicative of subgoal processes to integrate the association between stimulus and goal. Prior to a lapse of attention (i.e., failure to inhibit a response to "3") the LP1 was significantly attenuated on the preceding trial 2 indicating a failure of anticipatory goal-directed processing. The results are discussed in terms of models of sustained attention involving frontal and parietal cortices.

KW - Delayed intentions

KW - Early visual attention

KW - Go/no-go task

KW - Goal-directed behavior

KW - High-density ERPs

KW - Lapses of attention

KW - Selection negativity

KW - Sustained attention

UR - http://www.scopus.com/inward/record.url?scp=23744432072&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=23744432072&partnerID=8YFLogxK

U2 - 10.1016/j.neuroimage.2005.05.044

DO - 10.1016/j.neuroimage.2005.05.044

M3 - Article

C2 - 16024257

AN - SCOPUS:23744432072

VL - 27

SP - 587

EP - 601

JO - NeuroImage

JF - NeuroImage

SN - 1053-8119

IS - 3

ER -