Neuropeptide Y and agouti-related peptide mediate complementary functions of hyperphagia and reduced energy expenditure in leptin receptor deficiency

Na Luo, Genevieve Marcelin, Shun Mei Liu, Gary J. Schwartz, Streamson C. Chua, Jr.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Neuropeptide Y (NPY) and agouti-related peptide (AGRP) can produce hyperphagia, reduce energy expenditure, and promote triglyceride deposition in adipose depots. As these two neuropeptides are coexpressed within the hypothalamic arcuate nucleus and mediate a major portion of the obesity caused by leptin signaling deficiency, we sought to determine whether the two neuropeptides mediated identical or complementary actions. Because of separate neuropeptide receptors and signal transduction mechanisms, there is a possibility of distinct encoding systems for the feeding and energy expenditure aspects of leptin-regulated metabolism. We have genetically added NPY deficiency and/or AGRP deficiency to LEPR deficiency isolated to AGRP cells. Our results indicate that the obesity of LEPR deficiency in AGRP/NPY neurons can produce obesity with either AGRP or NPY alone with AGRP producing hyperphagia while NPY promotes reduced energy expenditure. The absence of both NPY and AGRP prevents the development of obesity attributable to isolated LEPR deficiency in AGRP/NPY neurons. Operant behavioral testing indicated that there were no alterations in the reward for a food pellet from the AGRP-specific LEPR deficiency.

Original languageEnglish (US)
Pages (from-to)883-889
Number of pages7
JournalEndocrinology
Volume152
Issue number3
DOIs
StatePublished - Mar 2011

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Leptin Receptors
Hyperphagia
Neuropeptide Y
Energy Metabolism
Peptides
Obesity
Leptin
Neuropeptides
Neuropeptide Receptors
Dasyproctidae
Neurons
Arcuate Nucleus of Hypothalamus
Reward
Signal Transduction
Triglycerides
Food

ASJC Scopus subject areas

  • Endocrinology

Cite this

Neuropeptide Y and agouti-related peptide mediate complementary functions of hyperphagia and reduced energy expenditure in leptin receptor deficiency. / Luo, Na; Marcelin, Genevieve; Liu, Shun Mei; Schwartz, Gary J.; Chua, Jr., Streamson C.

In: Endocrinology, Vol. 152, No. 3, 03.2011, p. 883-889.

Research output: Contribution to journalArticle

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