Neurological Gait Abnormalities Moderate the Functional Brain Signature of the Posture First Hypothesis

Roee Holtzer, Joe Verghese, Gilles Allali, Meltem Izzetoglu, Cuiling Wang, Jeannette R. Mahoney

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The posture first hypothesis suggests that under dual-task walking conditions older adults prioritize gait over cognitive task performance. Functional neural confirmation of this hypothesis, however, is lacking. Herein, we determined the functional neural correlates of the posture first hypothesis and hypothesized that the presence of neurological gait abnormalities (NGA) would moderate associations between brain activations, gait and cognitive performance. Using functional near-infrared spectroscopy we assessed changes in oxygenated hemoglobin levels in the pre-frontal cortex (PFC) during normal walk and walk while talk (WWT) conditions in a large cohort of non-demented older adults (n = 236; age = 75.5 ± 6.49 years; female = 51.7 %). NGA were defined as central (due to brain diseases) or peripheral (neuropathic gait) following a standardized neurological examination protocol. Double dissociations between brain activations and behavior emerged as a function of NGA. Higher oxygenation levels during WWT were related to better cognitive performance (estimate = 0.145; p 

Original languageEnglish (US)
Pages (from-to)334-343
Number of pages10
JournalBrain Topography
Volume29
Issue number2
DOIs
StatePublished - Mar 1 2016

Fingerprint

Posture
Gait
Brain
Near-Infrared Spectroscopy
Neurologic Examination
Task Performance and Analysis
Brain Diseases
Frontal Lobe
Walking
Hemoglobins

Keywords

  • Aging
  • Brain
  • Locomotion
  • Near-infrared spectroscopy

ASJC Scopus subject areas

  • Clinical Neurology
  • Anatomy
  • Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Neurological Gait Abnormalities Moderate the Functional Brain Signature of the Posture First Hypothesis. / Holtzer, Roee; Verghese, Joe; Allali, Gilles; Izzetoglu, Meltem; Wang, Cuiling; Mahoney, Jeannette R.

In: Brain Topography, Vol. 29, No. 2, 01.03.2016, p. 334-343.

Research output: Contribution to journalArticle

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