Neurologic manifestations associated with parvovirus B19 infection

Miltiadis Douvoyiannis, Nathan Litman, David L. Goldman

Research output: Contribution to journalArticlepeer-review

94 Scopus citations


Eighty-one cases of neurologic disease, including encephalitis, meningitis, stroke, and peripheral neuropathy, that were associated with parvovirus B19 infection were reviewed. Most patients were children, and two-thirds had central nervous system manifestations. One-third had altered immunity. Viral symptoms (odds ratio [OR], 5.7; P = .002), rash (OR, 11.5; P < .001), and peripheral nervous system involvement (OR, 12.1; P = .004) were more frequent in immunocompetent patients. Brain magnetic resonance imaging abnormalities were more frequent in patients with altered immunity (OR, 10; P = .04). In central nervous system disease, parvovirus B19 DNA was commonly detected in cerebrospinal fluid (81% of samples) and serum (85%), whereas specific antibodies were found in 33% of cerebrospinal fluid samples. Neurologic sequelae occurred in 22% of 77 patients with a known outcome, and some improvement occurred in 16%. No differences in the prevalence of sequealae were noted between immunocompetent patients (21% of whom experienced sequealae) and patients with altered immunity (25%) or between patients with central nervous system manifestations who received intravenous immunoglobulin with or without steroids and those patients with central nervous system manifestations who did not. Five patients died.

Original languageEnglish (US)
Pages (from-to)1713-1723
Number of pages11
JournalClinical Infectious Diseases
Issue number12
StatePublished - Jun 15 2009

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases


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