Neuroinflammatory basis of metabolic syndrome

Sudarshana Purkayastha, Dongsheng Cai

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

Inflammatory reaction is a fundamental defense mechanism against threat towards normal integrity and physiology. On the other hand, chronic diseases such as obesity, type 2 diabetes, hypertension and atherosclerosis, have been causally linked to chronic, low-grade inflammation in various metabolic tissues. Recent cross-disciplinary research has led to identification of hypothalamic inflammatory changes that are triggered by overnutrition, orchestrated by hypothalamic immune system, and sustained through metabolic syndrome-associated pathophysiology. While continuing research is actively trying to underpin the identity and mechanisms of these inflammatory stimuli and actions involved in metabolic syndrome disorders and related diseases, proinflammatory IκB kinase-β (IKKβ), the downstream nuclear transcription factor NF-κB and some related molecules in the hypothalamus were discovered to be pathogenically significant. This article is to summarize recent progresses in the field of neuroendocrine research addressing the central integrative role of neuroinflammation in metabolic syndrome components ranging from obesity, glucose intolerance to cardiovascular dysfunctions.

Original languageEnglish (US)
Pages (from-to)356-363
Number of pages8
JournalMolecular Metabolism
Volume2
Issue number4
DOIs
StatePublished - Nov 2013

Fingerprint

Obesity
Research
Overnutrition
Glucose Intolerance
Type 2 Diabetes Mellitus
Hypothalamus
Immune System
Atherosclerosis
Chronic Disease
Transcription Factors
Phosphotransferases
Hypertension
Inflammation

Keywords

  • CNS
  • Hypothalamus
  • IKKβ/NF-κB pathway
  • Inflammation
  • Obesity
  • Type 2 diabetes

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Neuroinflammatory basis of metabolic syndrome. / Purkayastha, Sudarshana; Cai, Dongsheng.

In: Molecular Metabolism, Vol. 2, No. 4, 11.2013, p. 356-363.

Research output: Contribution to journalArticle

Purkayastha, Sudarshana ; Cai, Dongsheng. / Neuroinflammatory basis of metabolic syndrome. In: Molecular Metabolism. 2013 ; Vol. 2, No. 4. pp. 356-363.
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