Neuroepigenomics and Human Disease

John M. Greally, Eric J. Nestler

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

There has been explosive growth in epigenetic research of the nervous system. Epigenetic regulatory processes are believed to mediate mechanisms through which environmental factors exert lifelong changes in the brain and its behavioral output. There is also the possibility that certain types of epigenetic modifications are passed onto offspring and influence their functioning through mechanisms that remain poorly understood. We provide a broader context for these neuroepigenomic questions by highlighting the range of epigenetic mechanisms that are employed by mammalian organisms and current technical challenges in their characterization, and how they contribute to understanding neurological and psychiatric diseases based on studies in animal models and humans. Although the field of neuroepigenomics holds considerable promise, major technical advances are needed to exploit the evolving knowledge for improved understanding of disease pathogenesis and improved therapeutics.

Original languageEnglish (US)
Title of host publicationGenomics, Circuits, and Pathways in Clinical Neuropsychiatry
PublisherElsevier Inc.
Pages73-91
Number of pages19
ISBN (Print)9780128001059
DOIs
StatePublished - Jun 21 2016

Keywords

  • Addiction
  • Chromatin
  • Depression
  • DNA methylation
  • Epigenetics
  • Histone acetylation
  • Histone methylation
  • Nucleosomes
  • Transcription

ASJC Scopus subject areas

  • Neuroscience(all)

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  • Cite this

    Greally, J. M., & Nestler, E. J. (2016). Neuroepigenomics and Human Disease. In Genomics, Circuits, and Pathways in Clinical Neuropsychiatry (pp. 73-91). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-800105-9.00005-6