Neuroendocrine profiles associated with energy intake, sleep, and stress in the night eating syndrome

Kelly C. Allison, Rexford S. Ahima, John P. O'Reardon, David F. Dinges, Vibhavasu Sharma, David E. Cummings, Moonseong Heo, Nicole S. Martino, Albert J. Stunkard

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

Context: Night eating syndrome (NES) is characterized by evening hyperphagia and frequent awakenings with ingestion of food. It is associated with obesity and depressed mood. Greater understanding of hormonal influences on NES is desirable. Objective: Our objective was to evaluate 25-h profiles of hormones involved in energy balance, sleep, and stress in NES. Design: Blood assays for glucose, insulin, ghrelin, leptin, melatonin, cortisol, TSH, and prolactin were sampled repeatedly among NES and control subjects. Food intake and depressive symptoms were assessed. Setting and Participants: Fifteen NES and 14 matched control participants stayed three nights in a General Clinical Research Center. Main Outcome Measures: We assessed differences between NES and control participants in the 25-h profiles of eight hormones. Results: Nocturnal food intake was higher among NES participants, although their daily calorie intake was similar to that of controls. Reflecting their increased nocturnal intake, insulin (P < 0.001) and glucose levels (P = 0.07) among NES participants were higher than those of controls. Ghrelin levels were significantly lower in NES participants than in controls from 0100-0900 h (P = 0.003). Levels of plasma cortisol, melatonin, leptin, and prolactin did not differ between groups, but there was a trend for TSH levels (P = 0.07) to be higher during the 25 h in NES. NES participants had greater depressive symptoms than controls (P < 0.001). The differences in the levels of glucose, insulin, and ghrelin between NES and controls are closely associated with nocturnal food intake.

Original languageEnglish (US)
Pages (from-to)6214-6217
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume90
Issue number11
DOIs
StatePublished - Nov 2005
Externally publishedYes

Fingerprint

Energy Intake
Sleep
Eating
Ghrelin
Melatonin
Insulin
Leptin
Prolactin
Hydrocortisone
Hormones
Glucose
Energy balance
Blood Glucose
Assays
Depression
Plasmas
Hyperphagia

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Allison, K. C., Ahima, R. S., O'Reardon, J. P., Dinges, D. F., Sharma, V., Cummings, D. E., ... Stunkard, A. J. (2005). Neuroendocrine profiles associated with energy intake, sleep, and stress in the night eating syndrome. Journal of Clinical Endocrinology and Metabolism, 90(11), 6214-6217. https://doi.org/10.1210/jc.2005-1018

Neuroendocrine profiles associated with energy intake, sleep, and stress in the night eating syndrome. / Allison, Kelly C.; Ahima, Rexford S.; O'Reardon, John P.; Dinges, David F.; Sharma, Vibhavasu; Cummings, David E.; Heo, Moonseong; Martino, Nicole S.; Stunkard, Albert J.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 90, No. 11, 11.2005, p. 6214-6217.

Research output: Contribution to journalArticle

Allison, KC, Ahima, RS, O'Reardon, JP, Dinges, DF, Sharma, V, Cummings, DE, Heo, M, Martino, NS & Stunkard, AJ 2005, 'Neuroendocrine profiles associated with energy intake, sleep, and stress in the night eating syndrome', Journal of Clinical Endocrinology and Metabolism, vol. 90, no. 11, pp. 6214-6217. https://doi.org/10.1210/jc.2005-1018
Allison, Kelly C. ; Ahima, Rexford S. ; O'Reardon, John P. ; Dinges, David F. ; Sharma, Vibhavasu ; Cummings, David E. ; Heo, Moonseong ; Martino, Nicole S. ; Stunkard, Albert J. / Neuroendocrine profiles associated with energy intake, sleep, and stress in the night eating syndrome. In: Journal of Clinical Endocrinology and Metabolism. 2005 ; Vol. 90, No. 11. pp. 6214-6217.
@article{0b8e8c0f49044c07b79b90b4de79a2ce,
title = "Neuroendocrine profiles associated with energy intake, sleep, and stress in the night eating syndrome",
abstract = "Context: Night eating syndrome (NES) is characterized by evening hyperphagia and frequent awakenings with ingestion of food. It is associated with obesity and depressed mood. Greater understanding of hormonal influences on NES is desirable. Objective: Our objective was to evaluate 25-h profiles of hormones involved in energy balance, sleep, and stress in NES. Design: Blood assays for glucose, insulin, ghrelin, leptin, melatonin, cortisol, TSH, and prolactin were sampled repeatedly among NES and control subjects. Food intake and depressive symptoms were assessed. Setting and Participants: Fifteen NES and 14 matched control participants stayed three nights in a General Clinical Research Center. Main Outcome Measures: We assessed differences between NES and control participants in the 25-h profiles of eight hormones. Results: Nocturnal food intake was higher among NES participants, although their daily calorie intake was similar to that of controls. Reflecting their increased nocturnal intake, insulin (P < 0.001) and glucose levels (P = 0.07) among NES participants were higher than those of controls. Ghrelin levels were significantly lower in NES participants than in controls from 0100-0900 h (P = 0.003). Levels of plasma cortisol, melatonin, leptin, and prolactin did not differ between groups, but there was a trend for TSH levels (P = 0.07) to be higher during the 25 h in NES. NES participants had greater depressive symptoms than controls (P < 0.001). The differences in the levels of glucose, insulin, and ghrelin between NES and controls are closely associated with nocturnal food intake.",
author = "Allison, {Kelly C.} and Ahima, {Rexford S.} and O'Reardon, {John P.} and Dinges, {David F.} and Vibhavasu Sharma and Cummings, {David E.} and Moonseong Heo and Martino, {Nicole S.} and Stunkard, {Albert J.}",
year = "2005",
month = "11",
doi = "10.1210/jc.2005-1018",
language = "English (US)",
volume = "90",
pages = "6214--6217",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "The Endocrine Society",
number = "11",

}

TY - JOUR

T1 - Neuroendocrine profiles associated with energy intake, sleep, and stress in the night eating syndrome

AU - Allison, Kelly C.

AU - Ahima, Rexford S.

AU - O'Reardon, John P.

AU - Dinges, David F.

AU - Sharma, Vibhavasu

AU - Cummings, David E.

AU - Heo, Moonseong

AU - Martino, Nicole S.

AU - Stunkard, Albert J.

PY - 2005/11

Y1 - 2005/11

N2 - Context: Night eating syndrome (NES) is characterized by evening hyperphagia and frequent awakenings with ingestion of food. It is associated with obesity and depressed mood. Greater understanding of hormonal influences on NES is desirable. Objective: Our objective was to evaluate 25-h profiles of hormones involved in energy balance, sleep, and stress in NES. Design: Blood assays for glucose, insulin, ghrelin, leptin, melatonin, cortisol, TSH, and prolactin were sampled repeatedly among NES and control subjects. Food intake and depressive symptoms were assessed. Setting and Participants: Fifteen NES and 14 matched control participants stayed three nights in a General Clinical Research Center. Main Outcome Measures: We assessed differences between NES and control participants in the 25-h profiles of eight hormones. Results: Nocturnal food intake was higher among NES participants, although their daily calorie intake was similar to that of controls. Reflecting their increased nocturnal intake, insulin (P < 0.001) and glucose levels (P = 0.07) among NES participants were higher than those of controls. Ghrelin levels were significantly lower in NES participants than in controls from 0100-0900 h (P = 0.003). Levels of plasma cortisol, melatonin, leptin, and prolactin did not differ between groups, but there was a trend for TSH levels (P = 0.07) to be higher during the 25 h in NES. NES participants had greater depressive symptoms than controls (P < 0.001). The differences in the levels of glucose, insulin, and ghrelin between NES and controls are closely associated with nocturnal food intake.

AB - Context: Night eating syndrome (NES) is characterized by evening hyperphagia and frequent awakenings with ingestion of food. It is associated with obesity and depressed mood. Greater understanding of hormonal influences on NES is desirable. Objective: Our objective was to evaluate 25-h profiles of hormones involved in energy balance, sleep, and stress in NES. Design: Blood assays for glucose, insulin, ghrelin, leptin, melatonin, cortisol, TSH, and prolactin were sampled repeatedly among NES and control subjects. Food intake and depressive symptoms were assessed. Setting and Participants: Fifteen NES and 14 matched control participants stayed three nights in a General Clinical Research Center. Main Outcome Measures: We assessed differences between NES and control participants in the 25-h profiles of eight hormones. Results: Nocturnal food intake was higher among NES participants, although their daily calorie intake was similar to that of controls. Reflecting their increased nocturnal intake, insulin (P < 0.001) and glucose levels (P = 0.07) among NES participants were higher than those of controls. Ghrelin levels were significantly lower in NES participants than in controls from 0100-0900 h (P = 0.003). Levels of plasma cortisol, melatonin, leptin, and prolactin did not differ between groups, but there was a trend for TSH levels (P = 0.07) to be higher during the 25 h in NES. NES participants had greater depressive symptoms than controls (P < 0.001). The differences in the levels of glucose, insulin, and ghrelin between NES and controls are closely associated with nocturnal food intake.

UR - http://www.scopus.com/inward/record.url?scp=27744533507&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=27744533507&partnerID=8YFLogxK

U2 - 10.1210/jc.2005-1018

DO - 10.1210/jc.2005-1018

M3 - Article

VL - 90

SP - 6214

EP - 6217

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 11

ER -