Neurocognitive, psychiatric, and substance use characteristics in opioid dependent adults

Franchesca Arias, Julia H. Arnsten, Chinazo O. Cunningham, Kelly Coulehan, Abigail Batchelder, Mia Brisbane, Katie Segal, Monica Rivera-Mindt

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Aims: To describe neurocognitive function among opioid-dependent adults seeking buprenorphine treatment and to explore the impact of lifetime psychiatric conditions on neurocognitive function. To explore the additive interaction of patient-based characteristics that may help to inform treatment. Design: Cross-sectional assessment of neurocognitive function, substance use, and psychiatric characteristics of adults seeking buprenorphine treatment within substance use treatment centers in New York City. Participants: Thirty-eight opioid-dependent adults seeking buprenorphine treatment. Measurements: A comprehensive battery, which included measures of executive functioning, learning, memory, verbal fluency, attention, processing speed, and motor functioning were administered. The Wide Range Achievement Test-Third Edition, the Composite International Diagnostic Interview, and an audio computer assisted structured interview were also completed. Correlations and independent sample t-tests were used to ascertain group differences. Findings: Thirty-nine percent of participants were impaired in global neurocognitive function (n = 15). Over one third were impaired in either: learning (n = 28), memory (n = 26), executive functioning (n = 17), motor functioning (n = 17), attention/working memory (n = 14) or verbal fluency (n = 12). Lifetime history of alcohol dependence was associated with impairment in global neurocognitive, executive functioning, and motor functioning. Lifetime history of cocaine dependence was associated with impairment in executive functioning and motor functioning (all p's <0.05). Major depressive disorder history was not associated with neurocognitive impairment. Conclusions: Among this sample of opioid-dependent adults, there were high rates of global and domain-specific neurocognitive impairment, with severe impairment in learning and memory. Lifetime alcohol and cocaine dependence were associated with greater neurocognitive impairment, particularly in executive functioning. Because executive functioning is critical for decision-making and learning/memory dysfunction may interfere with information encoding, these findings suggest that opioid-dependent adults may require enhanced support for medical decision-making.

Original languageEnglish (US)
Pages (from-to)137-143
Number of pages7
JournalAddictive Behaviors
Volume60
DOIs
StatePublished - Sep 1 2016

Fingerprint

Opioid Analgesics
Psychiatry
Buprenorphine
Data storage equipment
Cocaine-Related Disorders
Learning
Cocaine
Alcoholism
Decision making
Alcohols
Interviews
Therapeutics
Verbal Learning
Major Depressive Disorder
Short-Term Memory
Decision Making
Composite materials
Processing

Keywords

  • Buprenorphine treatment
  • Depression
  • Neurocognitive performance
  • Opioid dependence
  • Substance use disorders

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology
  • Toxicology
  • Medicine (miscellaneous)

Cite this

Neurocognitive, psychiatric, and substance use characteristics in opioid dependent adults. / Arias, Franchesca; Arnsten, Julia H.; Cunningham, Chinazo O.; Coulehan, Kelly; Batchelder, Abigail; Brisbane, Mia; Segal, Katie; Rivera-Mindt, Monica.

In: Addictive Behaviors, Vol. 60, 01.09.2016, p. 137-143.

Research output: Contribution to journalArticle

Arias, Franchesca ; Arnsten, Julia H. ; Cunningham, Chinazo O. ; Coulehan, Kelly ; Batchelder, Abigail ; Brisbane, Mia ; Segal, Katie ; Rivera-Mindt, Monica. / Neurocognitive, psychiatric, and substance use characteristics in opioid dependent adults. In: Addictive Behaviors. 2016 ; Vol. 60. pp. 137-143.
@article{0a1a54092fb34b209bcd269f3800fc01,
title = "Neurocognitive, psychiatric, and substance use characteristics in opioid dependent adults",
abstract = "Aims: To describe neurocognitive function among opioid-dependent adults seeking buprenorphine treatment and to explore the impact of lifetime psychiatric conditions on neurocognitive function. To explore the additive interaction of patient-based characteristics that may help to inform treatment. Design: Cross-sectional assessment of neurocognitive function, substance use, and psychiatric characteristics of adults seeking buprenorphine treatment within substance use treatment centers in New York City. Participants: Thirty-eight opioid-dependent adults seeking buprenorphine treatment. Measurements: A comprehensive battery, which included measures of executive functioning, learning, memory, verbal fluency, attention, processing speed, and motor functioning were administered. The Wide Range Achievement Test-Third Edition, the Composite International Diagnostic Interview, and an audio computer assisted structured interview were also completed. Correlations and independent sample t-tests were used to ascertain group differences. Findings: Thirty-nine percent of participants were impaired in global neurocognitive function (n = 15). Over one third were impaired in either: learning (n = 28), memory (n = 26), executive functioning (n = 17), motor functioning (n = 17), attention/working memory (n = 14) or verbal fluency (n = 12). Lifetime history of alcohol dependence was associated with impairment in global neurocognitive, executive functioning, and motor functioning. Lifetime history of cocaine dependence was associated with impairment in executive functioning and motor functioning (all p's <0.05). Major depressive disorder history was not associated with neurocognitive impairment. Conclusions: Among this sample of opioid-dependent adults, there were high rates of global and domain-specific neurocognitive impairment, with severe impairment in learning and memory. Lifetime alcohol and cocaine dependence were associated with greater neurocognitive impairment, particularly in executive functioning. Because executive functioning is critical for decision-making and learning/memory dysfunction may interfere with information encoding, these findings suggest that opioid-dependent adults may require enhanced support for medical decision-making.",
keywords = "Buprenorphine treatment, Depression, Neurocognitive performance, Opioid dependence, Substance use disorders",
author = "Franchesca Arias and Arnsten, {Julia H.} and Cunningham, {Chinazo O.} and Kelly Coulehan and Abigail Batchelder and Mia Brisbane and Katie Segal and Monica Rivera-Mindt",
year = "2016",
month = "9",
day = "1",
doi = "10.1016/j.addbeh.2016.03.018",
language = "English (US)",
volume = "60",
pages = "137--143",
journal = "Addictive Behaviors",
issn = "0306-4603",
publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Neurocognitive, psychiatric, and substance use characteristics in opioid dependent adults

AU - Arias, Franchesca

AU - Arnsten, Julia H.

AU - Cunningham, Chinazo O.

AU - Coulehan, Kelly

AU - Batchelder, Abigail

AU - Brisbane, Mia

AU - Segal, Katie

AU - Rivera-Mindt, Monica

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Aims: To describe neurocognitive function among opioid-dependent adults seeking buprenorphine treatment and to explore the impact of lifetime psychiatric conditions on neurocognitive function. To explore the additive interaction of patient-based characteristics that may help to inform treatment. Design: Cross-sectional assessment of neurocognitive function, substance use, and psychiatric characteristics of adults seeking buprenorphine treatment within substance use treatment centers in New York City. Participants: Thirty-eight opioid-dependent adults seeking buprenorphine treatment. Measurements: A comprehensive battery, which included measures of executive functioning, learning, memory, verbal fluency, attention, processing speed, and motor functioning were administered. The Wide Range Achievement Test-Third Edition, the Composite International Diagnostic Interview, and an audio computer assisted structured interview were also completed. Correlations and independent sample t-tests were used to ascertain group differences. Findings: Thirty-nine percent of participants were impaired in global neurocognitive function (n = 15). Over one third were impaired in either: learning (n = 28), memory (n = 26), executive functioning (n = 17), motor functioning (n = 17), attention/working memory (n = 14) or verbal fluency (n = 12). Lifetime history of alcohol dependence was associated with impairment in global neurocognitive, executive functioning, and motor functioning. Lifetime history of cocaine dependence was associated with impairment in executive functioning and motor functioning (all p's <0.05). Major depressive disorder history was not associated with neurocognitive impairment. Conclusions: Among this sample of opioid-dependent adults, there were high rates of global and domain-specific neurocognitive impairment, with severe impairment in learning and memory. Lifetime alcohol and cocaine dependence were associated with greater neurocognitive impairment, particularly in executive functioning. Because executive functioning is critical for decision-making and learning/memory dysfunction may interfere with information encoding, these findings suggest that opioid-dependent adults may require enhanced support for medical decision-making.

AB - Aims: To describe neurocognitive function among opioid-dependent adults seeking buprenorphine treatment and to explore the impact of lifetime psychiatric conditions on neurocognitive function. To explore the additive interaction of patient-based characteristics that may help to inform treatment. Design: Cross-sectional assessment of neurocognitive function, substance use, and psychiatric characteristics of adults seeking buprenorphine treatment within substance use treatment centers in New York City. Participants: Thirty-eight opioid-dependent adults seeking buprenorphine treatment. Measurements: A comprehensive battery, which included measures of executive functioning, learning, memory, verbal fluency, attention, processing speed, and motor functioning were administered. The Wide Range Achievement Test-Third Edition, the Composite International Diagnostic Interview, and an audio computer assisted structured interview were also completed. Correlations and independent sample t-tests were used to ascertain group differences. Findings: Thirty-nine percent of participants were impaired in global neurocognitive function (n = 15). Over one third were impaired in either: learning (n = 28), memory (n = 26), executive functioning (n = 17), motor functioning (n = 17), attention/working memory (n = 14) or verbal fluency (n = 12). Lifetime history of alcohol dependence was associated with impairment in global neurocognitive, executive functioning, and motor functioning. Lifetime history of cocaine dependence was associated with impairment in executive functioning and motor functioning (all p's <0.05). Major depressive disorder history was not associated with neurocognitive impairment. Conclusions: Among this sample of opioid-dependent adults, there were high rates of global and domain-specific neurocognitive impairment, with severe impairment in learning and memory. Lifetime alcohol and cocaine dependence were associated with greater neurocognitive impairment, particularly in executive functioning. Because executive functioning is critical for decision-making and learning/memory dysfunction may interfere with information encoding, these findings suggest that opioid-dependent adults may require enhanced support for medical decision-making.

KW - Buprenorphine treatment

KW - Depression

KW - Neurocognitive performance

KW - Opioid dependence

KW - Substance use disorders

UR - http://www.scopus.com/inward/record.url?scp=84964469197&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84964469197&partnerID=8YFLogxK

U2 - 10.1016/j.addbeh.2016.03.018

DO - 10.1016/j.addbeh.2016.03.018

M3 - Article

VL - 60

SP - 137

EP - 143

JO - Addictive Behaviors

JF - Addictive Behaviors

SN - 0306-4603

ER -