TY - JOUR
T1 - Neurobiological mechanisms of state-dependent learning
AU - Radulovic, Jelena
AU - Jovasevic, Vladimir
AU - Meyer, Mariah AA
N1 - Publisher Copyright:
© 2017
PY - 2017/8
Y1 - 2017/8
N2 - State-dependent learning (SDL) is a phenomenon relating to information storage and retrieval restricted to discrete states. While extensively studied using psychopharmacological approaches, SDL has not been subjected to rigorous neuroscientific study. Here we present an overview of approaches historically used to induce SDL, and highlight some of the known neurobiological mechanisms, in particular those related to inhibitory neurotransmission and its regulation by microRNAs (miR). We also propose novel cellular and circuit mechanisms as contributing factors. Lastly, we discuss the implications of advancing our knowledge on SDL, both for most fundamental processes of learning and memory as well as for development and maintenance of psychopathology.
AB - State-dependent learning (SDL) is a phenomenon relating to information storage and retrieval restricted to discrete states. While extensively studied using psychopharmacological approaches, SDL has not been subjected to rigorous neuroscientific study. Here we present an overview of approaches historically used to induce SDL, and highlight some of the known neurobiological mechanisms, in particular those related to inhibitory neurotransmission and its regulation by microRNAs (miR). We also propose novel cellular and circuit mechanisms as contributing factors. Lastly, we discuss the implications of advancing our knowledge on SDL, both for most fundamental processes of learning and memory as well as for development and maintenance of psychopathology.
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U2 - 10.1016/j.conb.2017.05.013
DO - 10.1016/j.conb.2017.05.013
M3 - Review article
C2 - 28558266
AN - SCOPUS:85019736981
SN - 0959-4388
VL - 45
SP - 92
EP - 98
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
ER -