Neural population dynamics in human motor cortex during movements in people with ALS

Chethan Pandarinath, Vikash Gilja, Christine H. Blabe, Paul Nuyujukian, Anish A. Sarma, Brittany L. Sorice, Emad N. Eskandar, Leigh R. Hochberg, Jaimie M. Henderson, Krishna V. Shenoy

Research output: Contribution to journalArticle

27 Scopus citations


The prevailing view of motor cortex holds that motor cortical neural activity represents muscle or movement parameters. However, recent studies in non-human primates have shown that neural activity does not simply represent muscle or movement parameters; instead, its temporal structure is well-described by a dynamical system where activity during movement evolves lawfully from an initial pre-movement state. In this study, we analyze neuronal ensemble activity in motor cortex in two clinical trial participants diagnosed with Amyotrophic Lateral Sclerosis (ALS). We find that activity in human motor cortex has similar dynamical structure to that of non-human primates, indicating that human motor cortex contains a similar underlying dynamical system for movement generation.

Original languageEnglish (US)
Article numbere07436
Issue numberJUNE
StatePublished - Jun 23 2015


ASJC Scopus subject areas

  • Neuroscience(all)
  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Pandarinath, C., Gilja, V., Blabe, C. H., Nuyujukian, P., Sarma, A. A., Sorice, B. L., Eskandar, E. N., Hochberg, L. R., Henderson, J. M., & Shenoy, K. V. (2015). Neural population dynamics in human motor cortex during movements in people with ALS. eLife, 4(JUNE), [e07436].