Nephrotoxicity of recreational party drugs

Linda Berney-Meyer, Tracey Putt, John Schollum, Robert Walker

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

N-benzylpiperazine (BZP) is the active ingredient in recreational 'party' pills with a stimulant, euphoric mechanism of action akin to that of 3,4-methylenedioxymethamphetamine (MDMA or ecstasy). Many people (ab)use BZP-based party pills usually without any significant toxic effects. However, nephrotoxicity secondary to hyperthermia and rhabdomyolysis has been reported. Another serious renal-related side-effect is hyponatraemia with acute cerebral oedema. There is also evidence that these agents may have a specific toxic effect producing acute kidney injury. Thus, acute kidney injury either direct or secondary to the effects of BZP or MDMA need to be considered when any individual presents with symptoms of a recreational party drug overdose. N-benzylpiperazine (BZP) is a popular recreational party drug. There is a potential for acute kidney injury, and this needs to be considered when any individual presents with symptoms of recreational drug overdose with 3,4-methylenedioxymethamphetamine (MDMA) and/or BZP components.

Original languageEnglish (US)
Pages (from-to)99-103
Number of pages5
JournalNephrology
Volume17
Issue number2
DOIs
StatePublished - Feb 2012
Externally publishedYes

Fingerprint

Street Drugs
N-Methyl-3,4-methylenedioxyamphetamine
Acute Kidney Injury
Drug Overdose
Poisons
Rhabdomyolysis
Hyponatremia
Brain Edema
Fever
N-benzylpiperazine
Kidney

Keywords

  • acute kidney injury
  • N-benzylpiperazine
  • nephrotoxicity
  • recreational drug

ASJC Scopus subject areas

  • Nephrology

Cite this

Berney-Meyer, L., Putt, T., Schollum, J., & Walker, R. (2012). Nephrotoxicity of recreational party drugs. Nephrology, 17(2), 99-103. https://doi.org/10.1111/j.1440-1797.2011.01537.x

Nephrotoxicity of recreational party drugs. / Berney-Meyer, Linda; Putt, Tracey; Schollum, John; Walker, Robert.

In: Nephrology, Vol. 17, No. 2, 02.2012, p. 99-103.

Research output: Contribution to journalArticle

Berney-Meyer, L, Putt, T, Schollum, J & Walker, R 2012, 'Nephrotoxicity of recreational party drugs', Nephrology, vol. 17, no. 2, pp. 99-103. https://doi.org/10.1111/j.1440-1797.2011.01537.x
Berney-Meyer L, Putt T, Schollum J, Walker R. Nephrotoxicity of recreational party drugs. Nephrology. 2012 Feb;17(2):99-103. https://doi.org/10.1111/j.1440-1797.2011.01537.x
Berney-Meyer, Linda ; Putt, Tracey ; Schollum, John ; Walker, Robert. / Nephrotoxicity of recreational party drugs. In: Nephrology. 2012 ; Vol. 17, No. 2. pp. 99-103.
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