Nectin family of cell-adhesion molecules: Structural and molecular aspects of function and specificity

Dibyendu Samanta, Steven C. Almo

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Cell-cell adhesive processes are central to the physiology of multicellular organisms. A number of cell surface molecules contribute to cell-cell adhesion, and the dysfunction of adhesive processes underlies numerous developmental defects and inherited diseases. The nectins, a family of four immunoglobulin superfamily members (nectin-1 to -4), interact through their extracellular domains to support cell-cell adhesion. While both homophilic and heterophilic interactions among the nectins are implicated in cell-cell adhesion, cell-based and biochemical studies suggest heterophilic interactions are stronger than homophilic interactions and control a range of physiological processes. In addition to interactions within the nectin family, heterophilic associations with nectin-like molecules, immune receptors, and viral glycoproteins support a wide range of biological functions, including immune modulation, cancer progression, host-pathogen interactions and immune evasion. We review current structural and molecular knowledge of nectin recognition processes, with a focus on the biochemical and biophysical determinants of affinity and selectivity that drive distinct nectin associations. These proteins and interactions are discussed as potential targets for immunotherapy.

Original languageEnglish (US)
Pages (from-to)645-658
Number of pages14
JournalCellular and Molecular Life Sciences
Volume72
Issue number4
DOIs
StatePublished - 2015

Fingerprint

Cell Adhesion Molecules
Cell Adhesion
Adhesives
Physiological Phenomena
Immune Evasion
Host-Pathogen Interactions
nectins
Immunotherapy
Immunoglobulins
Glycoproteins
Cell Count
Neoplasms
Proteins

Keywords

  • Cadherin
  • Crystal structures
  • Immune receptors
  • Immunoglobulin fold
  • Nectin
  • Nectin homodimers
  • Nectin-like molecules
  • Viral entry receptors

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Molecular Medicine
  • Pharmacology
  • Cellular and Molecular Neuroscience

Cite this

Nectin family of cell-adhesion molecules : Structural and molecular aspects of function and specificity. / Samanta, Dibyendu; Almo, Steven C.

In: Cellular and Molecular Life Sciences, Vol. 72, No. 4, 2015, p. 645-658.

Research output: Contribution to journalArticle

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