Nature of the water permeability increase induced by antidiuretic hormone (ADH) in toad urinary bladder and related tissues

A. Finkelstein

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

In artificial lipid bilayer membranes, the ratio of the water permeability coefficient (P(d)(water)) to the permeability coefficient of an arbitrary nonelectrolyte such as n butyramide (P(d)(n butyramide)) remains relatively constant with changes in lipid composition and temperature, even though the individual P(d)'s increase more than 100 fold. The author proposes that this is a general rule that also holds for the lipid bilayers of cells and tissues, and that therefore if P(d)(water)/P(d)(solute) greatly exceeds the value found for artificial lipid bilayers (where 'solute' is a molecule, such as 1,6 hexanediol or n butyramide, that crosses the cell membrane by a solubility diffusion mechanism without the aid of a special transporting system), then water crosses the cell membrane via aqueous pores. Applying this criterion to the toad urinary bladder, the author finds that even in the unstimulated bladder, water probably crosses the luminal membrane primarily through small aqueous pores, and that this is almost certainly the case after antidiuretic hormone (ADH) stimulation. He suggests that ADH stimulation ultimately leads either to formation (or enlargement) of pores, by the rearrangement of preexisting subunits, or to an unplugging of these pores.

Original languageEnglish (US)
Pages (from-to)137-143
Number of pages7
JournalJournal of General Physiology
Volume68
Issue number2
StatePublished - 1976

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Vasopressins
Anura
Permeability
Urinary Bladder
Lipid Bilayers
Water
Cell Membrane
Membranes
Solubility
Lipids
Temperature
butyramide

ASJC Scopus subject areas

  • Physiology

Cite this

Nature of the water permeability increase induced by antidiuretic hormone (ADH) in toad urinary bladder and related tissues. / Finkelstein, A.

In: Journal of General Physiology, Vol. 68, No. 2, 1976, p. 137-143.

Research output: Contribution to journalArticle

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