Naturally occurring mutations of the extracellular Ca2+-sensing receptor: Implications for its structure and function

Jianxin Hu, Allen M. Spiegel

Research output: Contribution to journalReview articlepeer-review

108 Scopus citations

Abstract

The extracellular Ca2+-sensing receptor is a member of the G-protein-coupled receptor family 3 in which agonists bind to a dimeric Venus-flytrap domain in the extracellular portion of the receptor. How agonist binding to this domain leads to activation of the seven-transmembrane domain is a major unresolved question. Information derived from the three-dimensional structure of the Venus-flytrap domain of the related metabotropic glutamate type 1 receptor, and from naturally occurring mutations of the Ca 2+-sensing receptor identified in subjects with familial hypocalciuric hypercalcemia and autosomal dominant hypocalcemia offers new insights into the mechanism of receptor activation, and into the mechanism of action of allosteric modulators of the receptor.

Original languageEnglish (US)
Pages (from-to)282-288
Number of pages7
JournalTrends in Endocrinology and Metabolism
Volume14
Issue number6
DOIs
StatePublished - Aug 2003
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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