Natural history of established low grade cervical intraepithelial (CIN 1) lesions

Nisha Bansal, Jason D. Wright, Carmel J. Cohen, Thomas J. Herzog

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

The aim of the present study was to ascertain the natural history of cervical intraepithelial lesions 1 (CIN 1) and to develop recommendations to optimize follow-up. Patients and Methods: Patients referred for colposcopy from January, 1996 to July, 2005 were reviewed. A prospectively maintained database was quarried for demographic, clinical, and pathologic data. Results: The cohort included 1,001 patients with CIN 1. At 6 months, 330 patients (49%) regressed to normal, 305 (45%) had persistent low grade, while 45 (7%) progressed to high grade lesions. At 12 months, of those with negative pathology at 6 months, 200 (80%) remained negative, 42 (16%) demonstrated low grade and 9 (4%) progressed to high grade lesions. Of those with low grade lesions at 6 months, 131 (50%) regressed, 121 (46%) had persistent low grade, and 10 (4%) progressed to high grade lesions. Conclusion: Our data demonstrates a low rate of progression for CIN 1, suggesting it may be reasonable to prolong the screening interval in women with CIN 1.

Original languageEnglish (US)
Pages (from-to)1763-1766
Number of pages4
JournalAnticancer Research
Volume28
Issue number3 B
StatePublished - May 1 2008
Externally publishedYes

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Natural History
Colposcopy
Demography
Databases
Pathology

Keywords

  • Cervical dysplasia
  • Cervical intraepithelial neoplasia
  • Colposcopy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Bansal, N., Wright, J. D., Cohen, C. J., & Herzog, T. J. (2008). Natural history of established low grade cervical intraepithelial (CIN 1) lesions. Anticancer Research, 28(3 B), 1763-1766.

Natural history of established low grade cervical intraepithelial (CIN 1) lesions. / Bansal, Nisha; Wright, Jason D.; Cohen, Carmel J.; Herzog, Thomas J.

In: Anticancer Research, Vol. 28, No. 3 B, 01.05.2008, p. 1763-1766.

Research output: Contribution to journalArticle

Bansal, N, Wright, JD, Cohen, CJ & Herzog, TJ 2008, 'Natural history of established low grade cervical intraepithelial (CIN 1) lesions', Anticancer Research, vol. 28, no. 3 B, pp. 1763-1766.
Bansal, Nisha ; Wright, Jason D. ; Cohen, Carmel J. ; Herzog, Thomas J. / Natural history of established low grade cervical intraepithelial (CIN 1) lesions. In: Anticancer Research. 2008 ; Vol. 28, No. 3 B. pp. 1763-1766.
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