@article{f1d84af51446497f8b1228f172300199,
title = "Nar1 deficiency results in shortened lifespan and sensitivity to paraquat that is rescued by increased expression of mitochondrial superoxide dismutase",
abstract = "Saccharomyces cerevisiae Nar1p is an essential Fe/S protein that exhibits striking similarity to bacterial iron-only hydrogenases. Nar1p is required for the maturation of cytosolic and nuclear, but not of mitochondrial Fe/S proteins, and plays a role in modulating sensitivity to oxygen in both yeast and Caenorhabditis elegans through unknown mechanisms. Here we report that Nar1 deficiency results in shortened lifespan and sensitivity to paraquat that is rescued by increased expression of mitochondrial superoxide dismutase. These data suggest that Nar1p promotes protection against oxidative stress and define a new role for Nar1p in promoting replicative lifespan.",
keywords = "Lifespan, Mitochondrial superoxide dismutase, Nar1",
author = "Wei Zhao and Fang, {Bing Xiong} and Niu, {Yu Jie} and Liu, {Yi Na} and Bin Liu and Qi Peng and Li, {Jiang Bin} and Wasko, {Brian M.} and Delaney, {Joseph R.} and Kennedy, {Brian K.} and Yousin Suh and Zhou, {Zhong Jun} and Matt Kaeberlein and Liu, {Xin Guang}",
note = "Funding Information: This work was supported by National Natural Science Foundation of China ( 30871440 , 31101051 , 81170327 ), Natural Science Foundation of Guangdong Province ( 9252402301000002 ), the Technology Planning Project for University Research Institutions and Medical and Health Organizations of Dongguan City ( 2012108102022 ), the Science & Technology Innovation Fund of Guangdong Medical College ( STIF201102 ) and the Ph.D. Start-up Fund of Guangdong Medical College ( B2012061 ). JRD was supported by NIH Training Grant T32AG000057 . BMW was supported by NIH Training Grant T32ES007032 . We are grateful to Brett Robison, Mark McCormick, and Chong He for technical assistance and for supplying yeast strains and plasmids.",
year = "2014",
month = jun,
doi = "10.1016/j.mad.2014.01.007",
language = "English (US)",
volume = "138",
pages = "53--58",
journal = "Mechanisms of Ageing and Development",
issn = "0047-6374",
publisher = "Elsevier Ireland Ltd",
number = "1",
}