N-methyl-D-aspartate enhancement of phasic responses in primate neocortex

C. E. Schroeder; D. C. Javitt; M. Steinschneider; A. D. Mehta; S. J. Givre; H. G. Vaughan; J. C. Arezzo

doi:10.1007/PL00005635

N-methyl-D-aspartate enhancement of phasic responses in primate neocortex

C. E. Schroeder, D. C. Javitt, M. Steinschneider, A. D. Mehta, S. J. Givre, H. G. Vaughan, J. C. Arezzo

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

In area 17 of the awake macaque, disinhibition by blockade of GABA(A) receptors results in a marked elevation in neuronal excitability, with a particular focus in the supragranular laminae. We examined the possibility that the excitatory supragranular response is N-methyl-D-aspartate (NMDA)-mediated. Laminar activity profiles consisting of flash-evoked field potential, current source density (CSD) and multiunit activity (MUA) measures were obtained during striate cortex penetrations using multicontact electrodes that incorporated single or double microinjection cannulae. Profiles were recorded before and at successive time points after bicuculline induction of disinhibition. Both the noncompetitive NMDA antagonist MK-801 and the competitive antagonist APV reversed bicuculline effects, producing a normal laminar activity profile. NMDA-mediated enhancement of excitatory responses in the supragranular laminae of neocortex is believed to play a role in normal signal processing, as well as in epileptic manifestations.

Original language	English (US)
Pages (from-to)	271-278
Number of pages	8
Journal	Experimental Brain Research
Volume	114
Issue number	2
DOIs	https://doi.org/10.1007/PL00005635
State	Published - 1997

Keywords

Amplification
Awake monkey
Current source density analysis
Epilepsy
NMDA

ASJC Scopus subject areas

Neuroscience(all)

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10.1007/PL00005635

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title = "N-methyl-D-aspartate enhancement of phasic responses in primate neocortex",

abstract = "In area 17 of the awake macaque, disinhibition by blockade of GABA(A) receptors results in a marked elevation in neuronal excitability, with a particular focus in the supragranular laminae. We examined the possibility that the excitatory supragranular response is N-methyl-D-aspartate (NMDA)-mediated. Laminar activity profiles consisting of flash-evoked field potential, current source density (CSD) and multiunit activity (MUA) measures were obtained during striate cortex penetrations using multicontact electrodes that incorporated single or double microinjection cannulae. Profiles were recorded before and at successive time points after bicuculline induction of disinhibition. Both the noncompetitive NMDA antagonist MK-801 and the competitive antagonist APV reversed bicuculline effects, producing a normal laminar activity profile. NMDA-mediated enhancement of excitatory responses in the supragranular laminae of neocortex is believed to play a role in normal signal processing, as well as in epileptic manifestations.",

keywords = "Amplification, Awake monkey, Current source density analysis, Epilepsy, NMDA",

author = "Schroeder, {C. E.} and Javitt, {D. C.} and M. Steinschneider and Mehta, {A. D.} and Givre, {S. J.} and Vaughan, {H. G.} and Arezzo, {J. C.}",

note = "Funding Information: &p.2: wledgements This work was supported by MH47939, MH06723, by a grant from the James S. McDonnell Foundation and by the Rose F. Kennedy Center at Albert Einstein Core Grant. We thank Mona Litwak, Shirley Seto, Robert Lindsley and Chester Freeman for technical support, Linda O{\textquoteright}Donnell for secretarial assistance, Dr. S.U. Walkley and May Huang for histology and Howard Rubin for photography. We also thank (in alphabetical order) G. Karmos, S. Moshe and P.K. Stanton for comments on an earlier version of the manuscript.",

year = "1997",

doi = "10.1007/PL00005635",

language = "English (US)",

volume = "114",

pages = "271--278",

journal = "Experimental Brain Research",

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number = "2",

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T1 - N-methyl-D-aspartate enhancement of phasic responses in primate neocortex

AU - Schroeder, C. E.

AU - Javitt, D. C.

AU - Steinschneider, M.

AU - Mehta, A. D.

AU - Givre, S. J.

AU - Vaughan, H. G.

AU - Arezzo, J. C.

N1 - Funding Information: &p.2: wledgements This work was supported by MH47939, MH06723, by a grant from the James S. McDonnell Foundation and by the Rose F. Kennedy Center at Albert Einstein Core Grant. We thank Mona Litwak, Shirley Seto, Robert Lindsley and Chester Freeman for technical support, Linda O’Donnell for secretarial assistance, Dr. S.U. Walkley and May Huang for histology and Howard Rubin for photography. We also thank (in alphabetical order) G. Karmos, S. Moshe and P.K. Stanton for comments on an earlier version of the manuscript.

PY - 1997

Y1 - 1997

N2 - In area 17 of the awake macaque, disinhibition by blockade of GABA(A) receptors results in a marked elevation in neuronal excitability, with a particular focus in the supragranular laminae. We examined the possibility that the excitatory supragranular response is N-methyl-D-aspartate (NMDA)-mediated. Laminar activity profiles consisting of flash-evoked field potential, current source density (CSD) and multiunit activity (MUA) measures were obtained during striate cortex penetrations using multicontact electrodes that incorporated single or double microinjection cannulae. Profiles were recorded before and at successive time points after bicuculline induction of disinhibition. Both the noncompetitive NMDA antagonist MK-801 and the competitive antagonist APV reversed bicuculline effects, producing a normal laminar activity profile. NMDA-mediated enhancement of excitatory responses in the supragranular laminae of neocortex is believed to play a role in normal signal processing, as well as in epileptic manifestations.

AB - In area 17 of the awake macaque, disinhibition by blockade of GABA(A) receptors results in a marked elevation in neuronal excitability, with a particular focus in the supragranular laminae. We examined the possibility that the excitatory supragranular response is N-methyl-D-aspartate (NMDA)-mediated. Laminar activity profiles consisting of flash-evoked field potential, current source density (CSD) and multiunit activity (MUA) measures were obtained during striate cortex penetrations using multicontact electrodes that incorporated single or double microinjection cannulae. Profiles were recorded before and at successive time points after bicuculline induction of disinhibition. Both the noncompetitive NMDA antagonist MK-801 and the competitive antagonist APV reversed bicuculline effects, producing a normal laminar activity profile. NMDA-mediated enhancement of excitatory responses in the supragranular laminae of neocortex is believed to play a role in normal signal processing, as well as in epileptic manifestations.

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KW - Awake monkey

KW - Current source density analysis

KW - Epilepsy

KW - NMDA

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N-methyl-D-aspartate enhancement of phasic responses in primate neocortex

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