N-methyl-D-aspartate enhancement of phasic responses in primate neocortex

C. E. Schroeder, D. C. Javitt, Mitchell Steinschneider, A. D. Mehta, S. J. Givre, H. G. Vaughan, Joseph C. Arezzo

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

In area 17 of the awake macaque, disinhibition by blockade of GABA(A) receptors results in a marked elevation in neuronal excitability, with a particular focus in the supragranular laminae. We examined the possibility that the excitatory supragranular response is N-methyl-D-aspartate (NMDA)-mediated. Laminar activity profiles consisting of flash-evoked field potential, current source density (CSD) and multiunit activity (MUA) measures were obtained during striate cortex penetrations using multicontact electrodes that incorporated single or double microinjection cannulae. Profiles were recorded before and at successive time points after bicuculline induction of disinhibition. Both the noncompetitive NMDA antagonist MK-801 and the competitive antagonist APV reversed bicuculline effects, producing a normal laminar activity profile. NMDA-mediated enhancement of excitatory responses in the supragranular laminae of neocortex is believed to play a role in normal signal processing, as well as in epileptic manifestations.

Original languageEnglish (US)
Pages (from-to)271-278
Number of pages8
JournalExperimental Brain Research
Volume114
Issue number2
StatePublished - 1997

Fingerprint

Neocortex
N-Methylaspartate
Primates
Bicuculline
Dizocilpine Maleate
Microinjections
Macaca
Visual Cortex
GABA-A Receptors
Evoked Potentials
Electrodes

Keywords

  • Amplification
  • Awake monkey
  • Current source density analysis
  • Epilepsy
  • NMDA

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Schroeder, C. E., Javitt, D. C., Steinschneider, M., Mehta, A. D., Givre, S. J., Vaughan, H. G., & Arezzo, J. C. (1997). N-methyl-D-aspartate enhancement of phasic responses in primate neocortex. Experimental Brain Research, 114(2), 271-278.

N-methyl-D-aspartate enhancement of phasic responses in primate neocortex. / Schroeder, C. E.; Javitt, D. C.; Steinschneider, Mitchell; Mehta, A. D.; Givre, S. J.; Vaughan, H. G.; Arezzo, Joseph C.

In: Experimental Brain Research, Vol. 114, No. 2, 1997, p. 271-278.

Research output: Contribution to journalArticle

Schroeder, CE, Javitt, DC, Steinschneider, M, Mehta, AD, Givre, SJ, Vaughan, HG & Arezzo, JC 1997, 'N-methyl-D-aspartate enhancement of phasic responses in primate neocortex', Experimental Brain Research, vol. 114, no. 2, pp. 271-278.
Schroeder CE, Javitt DC, Steinschneider M, Mehta AD, Givre SJ, Vaughan HG et al. N-methyl-D-aspartate enhancement of phasic responses in primate neocortex. Experimental Brain Research. 1997;114(2):271-278.
Schroeder, C. E. ; Javitt, D. C. ; Steinschneider, Mitchell ; Mehta, A. D. ; Givre, S. J. ; Vaughan, H. G. ; Arezzo, Joseph C. / N-methyl-D-aspartate enhancement of phasic responses in primate neocortex. In: Experimental Brain Research. 1997 ; Vol. 114, No. 2. pp. 271-278.
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