Myopia stabilization and associated factors among participants in the correction of myopia evaluation trial (COMET)

Robert Hardy, Argye Hillis, Don Mutti, Richard Stone, Carol Taylor, Li Ming Dong, Melissa Fazzari, Jane Gwiazda, Leslie Hyman, Thomas Norton, Frank Thorn, Qinghua Zhang, Jane Gwiazda, Thomas Norton, Kenneth Grice, Christine Fortunato, Cara Weber, Alexandra Beale, David Kern, Sally BittingerDebanjali Ghosh, Rosanna Pacella, Frank Thorn, M. Cristina Leske, Mohamed Hussein, Li Ming Dong, Melissa Fazzari, Wei Hou, Elinor Schoenfeld, Lynette Dias, Rachel Harrison, Wen Zhu, Qinghua Zhang, Ying Wang, Ahmed Yassin, Elissa Schnall, Cristi Rau, Jennifer Thomas, Marcela Wasserman, Yi Ju Chen, Sakeena Ahmed, Leanne Merill, Lauretta Passanant, Maria Rodriguez, Allison Schmertz, Ann Park, Phyllis Neuschwender, Geeta Veeraraghavan, Angela Santomarco, Laura Sisti, Lydia Seib, Donald Everett, Wendy Marsh-Tootle, Katherine Niemann, Marcela Frazier, Catherine Baldwin, Carey Dillard, Kristine Becker, James Raley, Angela Rawden, Nicholas Harris, Trana Mars, Robert Rutstein, Daniel Kurtz, Erik Weissberg, Bruce Moore, Elise Harb, Robert Owens, Sheila Martin, Joanne Bolden, Justin Smith, David Kern, Sally Bittinger, Debanjali Ghosh, Benny Jaramillo, Stacy Hamlett, Laura Vasilakos, Sarah Gladstone, Chris Owens, Patricia Kowalski, Jennifer Hazelwood, Ruth Manny, Connie Crossnoe, Karen Fern, Sheila Deatherage, Charles Dudonis, S. Henry, Jennifer McLeod, Mamie Batres, Julio Quiralte, Giselle Garza, Gabynely Solis, Joan Do, Andy Ketcham, Mitchell Scheiman, Kathleen Zinzer, Karen Pollack, Timothy Lancaster, Theresa Elliott, Mark Bernhardt, Dan Ferrara, Jeff Miles, Scott Wilkins, Renee Wilkins, Jennifer Nicole Smith, Dawn D'Antonio, Lindsey Lear, Sandy Dang, Charles Sporer, Mary Jameson, Abby Grossman, Mariel Torres, Heather Jones, Melissa Madigan-Carr, Theresa Sanogo, Jo Ann Bailey

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

Purpose. To use the Gompertz function to estimate the age and the amount of myopia at stabilization and to evaluate associated factors in the Correction of Myopia Evaluation Trial (COMET) cohort, a large ethnically diverse group of myopic children. Methods. The COMET enrolled 469 ethnically diverse children aged 6 to younger than 12 years with spherical equivalent refraction between -1.25 and -4.50 diopters (D). Noncycloplegic refraction was measured semiannually for 4 years and annually thereafter. Right eye data were fit to individual Gompertz functions in participants with at least 6 years of follow-up and at least seven refraction measurements over 11 years. Function parameters were estimated using a nonlinear least squares procedure. Associated factors were evaluated using linear regression. Results. In total, 426 participants (91%) had valid Gompertz curve fits. The mean (SD) age at myopia stabilization was 15.61 (4.17) years, and the mean (SD) amount of myopia at stabilization was -4.87 (2.01) D. Ethnicity (P < 0.0001) but not sex or the number of myopic parents was associated with the age at stabilization. Ethnicity (P = 0.02) and the number of myopic parents (P = 0.01) but not sex were associated with myopia magnitude at stabilization. At stabilization, African Americans were youngest (mean age, 13.82 years) and had the least myopia (mean, -4.36 D). Participants with two versus no myopic parents had approximately 1.00 D more myopia at stabilization. The age and the amount of myopia at stabilization were correlated (r = -0.60, P < 0.0001). Conclusions. The Gompertz function provides estimates of the age and the amount of myopia at stabilization in an ethnically diverse cohort. These findings should provide guidance on the time course of myopia and on decisions regarding the type and timing of interventions.

Original languageEnglish (US)
Pages (from-to)7871-7883
Number of pages13
JournalInvestigative Ophthalmology and Visual Science
Volume54
Issue number13
DOIs
StatePublished - Oct 3 2013

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Keywords

  • Associated factors
  • Gompertz function
  • Myopia
  • Myopia progression
  • Myopia stabilization

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Hardy, R., Hillis, A., Mutti, D., Stone, R., Taylor, C., Dong, L. M., Fazzari, M., Gwiazda, J., Hyman, L., Norton, T., Thorn, F., Zhang, Q., Gwiazda, J., Norton, T., Grice, K., Fortunato, C., Weber, C., Beale, A., Kern, D., ... Bailey, J. A. (2013). Myopia stabilization and associated factors among participants in the correction of myopia evaluation trial (COMET). Investigative Ophthalmology and Visual Science, 54(13), 7871-7883. https://doi.org/10.1167/iovs.13-12403