Myocardial ischemia related to ergot alkaloids

A case report and literature review

B. S. Galer, Richard B. Lipton, S. Solomon, L. C. Newman, E. L H Spierings

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Ergotamine tartrate and methysergide are widely used headache treatments with important vasoconstrictive properties. We report a 31-year-old man with cluster headaches who developed severe, prolonged myocardial ischemia following combination therapy with ergotamine tartrate and methysergide. We reviewed the cardiovascular complications of each agent alone and in combination. Given the pharmacologic similarity of these agents, we propose that they may have additive or synergistic cardiac toxicity, at least in vulnerable individuals. We recommend caution when these agents are used together.

Original languageEnglish (US)
Pages (from-to)446-450
Number of pages5
JournalHeadache
Volume31
Issue number7
StatePublished - 1991

Fingerprint

Ergot Alkaloids
Ergotamine
Methysergide
Myocardial Ischemia
Cluster Headache
Headache
Therapeutics
Cardiotoxicity

Keywords

  • Coronary
  • Ergotamine
  • Methysergide
  • Vasoconstriction

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Galer, B. S., Lipton, R. B., Solomon, S., Newman, L. C., & Spierings, E. L. H. (1991). Myocardial ischemia related to ergot alkaloids: A case report and literature review. Headache, 31(7), 446-450.

Myocardial ischemia related to ergot alkaloids : A case report and literature review. / Galer, B. S.; Lipton, Richard B.; Solomon, S.; Newman, L. C.; Spierings, E. L H.

In: Headache, Vol. 31, No. 7, 1991, p. 446-450.

Research output: Contribution to journalArticle

Galer, BS, Lipton, RB, Solomon, S, Newman, LC & Spierings, ELH 1991, 'Myocardial ischemia related to ergot alkaloids: A case report and literature review', Headache, vol. 31, no. 7, pp. 446-450.
Galer BS, Lipton RB, Solomon S, Newman LC, Spierings ELH. Myocardial ischemia related to ergot alkaloids: A case report and literature review. Headache. 1991;31(7):446-450.
Galer, B. S. ; Lipton, Richard B. ; Solomon, S. ; Newman, L. C. ; Spierings, E. L H. / Myocardial ischemia related to ergot alkaloids : A case report and literature review. In: Headache. 1991 ; Vol. 31, No. 7. pp. 446-450.
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