Myocardial edema: Comparison of effects on filling volume and stiffness of the left ventricle in rats and pigs

Mehrdad M.R. Amirhamzeh, Daphne T. Hsu, Santos E. Cabreriza, Chao Xiang Jia, Henry M. Spotnitz

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Background. This study compared the adverse effects of crystalloid- induced myocardial edema on left ventricular (LV) compliance in small and large hearts. Methods. Plegisol (289 mOsm/L) was perfused into the coronary arteries of pigs (n = 8) and 1:1 dilute Plegisol (145 mOsm/L) into the coronary arteries of rats (n = 6). Pressure-volume relations, heart weight, and water content were then determined. The pressure-volume relations were compared using an volume at a pressure of 10 mm Hg. Results. Edema in rats was associated with significant (p < 0.05) increases in heart weight (1.1 ± 0.0 g versus 1.4 ± 0.1 g [average ± standard error of the mean]) and water content (76.8% ± 0.4% versus 81.3% ± 0.8%), but an increase in LV stiffness (7.91 ± 0.52 versus 9.27 ± 1.42) and a decrease in the LV volume at 10 mm Hg (0.25 ± 0.02 mL versus 0.14 ± 0.05 mL) were not statistically significant. Edema in pigs was associated with statistically significant (p < 0.05) increases in LV stiffness β (0.050 ± 0.004 versus 0.072 ± 0.008), heart weight (207 ± 8 g versus 274 ± 9 g), and water content (79.8% ± 0.6% versus 85.3% ± 0.6%) and a significant decrease in the LV volume at 10 mm Hg (88.4 ± 5.8 mL versus 60.4 ± 6.8 mL). Conclusions. Myocardial edema is associated with an increase in water content and LV stiffness and a decrease in the LV volume at 10 mm Hg in both species. In rats, however, the water content is smaller in the control state and a more hypotonic perfusate is needed to induce a given degree of edema.

Original languageEnglish (US)
Pages (from-to)1293-1297
Number of pages5
JournalAnnals of Thoracic Surgery
Volume63
Issue number5
DOIs
StatePublished - May 1 1997
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

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