Myocardial edema

Comparison of effects on filling volume and stiffness of the left ventricle in rats and pigs

Mehrdad M R Amirhamzeh, Daphne T. Hsu, Santos E. Cabreriza, Chao Xiang Jia, Henry M. Spotnitz

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background. This study compared the adverse effects of crystalloid- induced myocardial edema on left ventricular (LV) compliance in small and large hearts. Methods. Plegisol (289 mOsm/L) was perfused into the coronary arteries of pigs (n = 8) and 1:1 dilute Plegisol (145 mOsm/L) into the coronary arteries of rats (n = 6). Pressure-volume relations, heart weight, and water content were then determined. The pressure-volume relations were compared using an volume at a pressure of 10 mm Hg. Results. Edema in rats was associated with significant (p < 0.05) increases in heart weight (1.1 ± 0.0 g versus 1.4 ± 0.1 g [average ± standard error of the mean]) and water content (76.8% ± 0.4% versus 81.3% ± 0.8%), but an increase in LV stiffness (7.91 ± 0.52 versus 9.27 ± 1.42) and a decrease in the LV volume at 10 mm Hg (0.25 ± 0.02 mL versus 0.14 ± 0.05 mL) were not statistically significant. Edema in pigs was associated with statistically significant (p < 0.05) increases in LV stiffness β (0.050 ± 0.004 versus 0.072 ± 0.008), heart weight (207 ± 8 g versus 274 ± 9 g), and water content (79.8% ± 0.6% versus 85.3% ± 0.6%) and a significant decrease in the LV volume at 10 mm Hg (88.4 ± 5.8 mL versus 60.4 ± 6.8 mL). Conclusions. Myocardial edema is associated with an increase in water content and LV stiffness and a decrease in the LV volume at 10 mm Hg in both species. In rats, however, the water content is smaller in the control state and a more hypotonic perfusate is needed to induce a given degree of edema.

Original languageEnglish (US)
Pages (from-to)1293-1297
Number of pages5
JournalAnnals of Thoracic Surgery
Volume63
Issue number5
DOIs
StatePublished - May 1997
Externally publishedYes

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Heart Ventricles
Edema
Swine
Water
Pressure
Weights and Measures
Coronary Vessels
Cardiac Volume
Compliance
St. Thomas' Hospital cardioplegic solution

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Myocardial edema : Comparison of effects on filling volume and stiffness of the left ventricle in rats and pigs. / Amirhamzeh, Mehrdad M R; Hsu, Daphne T.; Cabreriza, Santos E.; Jia, Chao Xiang; Spotnitz, Henry M.

In: Annals of Thoracic Surgery, Vol. 63, No. 5, 05.1997, p. 1293-1297.

Research output: Contribution to journalArticle

Amirhamzeh, Mehrdad M R ; Hsu, Daphne T. ; Cabreriza, Santos E. ; Jia, Chao Xiang ; Spotnitz, Henry M. / Myocardial edema : Comparison of effects on filling volume and stiffness of the left ventricle in rats and pigs. In: Annals of Thoracic Surgery. 1997 ; Vol. 63, No. 5. pp. 1293-1297.
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abstract = "Background. This study compared the adverse effects of crystalloid- induced myocardial edema on left ventricular (LV) compliance in small and large hearts. Methods. Plegisol (289 mOsm/L) was perfused into the coronary arteries of pigs (n = 8) and 1:1 dilute Plegisol (145 mOsm/L) into the coronary arteries of rats (n = 6). Pressure-volume relations, heart weight, and water content were then determined. The pressure-volume relations were compared using an volume at a pressure of 10 mm Hg. Results. Edema in rats was associated with significant (p < 0.05) increases in heart weight (1.1 ± 0.0 g versus 1.4 ± 0.1 g [average ± standard error of the mean]) and water content (76.8{\%} ± 0.4{\%} versus 81.3{\%} ± 0.8{\%}), but an increase in LV stiffness (7.91 ± 0.52 versus 9.27 ± 1.42) and a decrease in the LV volume at 10 mm Hg (0.25 ± 0.02 mL versus 0.14 ± 0.05 mL) were not statistically significant. Edema in pigs was associated with statistically significant (p < 0.05) increases in LV stiffness β (0.050 ± 0.004 versus 0.072 ± 0.008), heart weight (207 ± 8 g versus 274 ± 9 g), and water content (79.8{\%} ± 0.6{\%} versus 85.3{\%} ± 0.6{\%}) and a significant decrease in the LV volume at 10 mm Hg (88.4 ± 5.8 mL versus 60.4 ± 6.8 mL). Conclusions. Myocardial edema is associated with an increase in water content and LV stiffness and a decrease in the LV volume at 10 mm Hg in both species. In rats, however, the water content is smaller in the control state and a more hypotonic perfusate is needed to induce a given degree of edema.",
author = "Amirhamzeh, {Mehrdad M R} and Hsu, {Daphne T.} and Cabreriza, {Santos E.} and Jia, {Chao Xiang} and Spotnitz, {Henry M.}",
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T1 - Myocardial edema

T2 - Comparison of effects on filling volume and stiffness of the left ventricle in rats and pigs

AU - Amirhamzeh, Mehrdad M R

AU - Hsu, Daphne T.

AU - Cabreriza, Santos E.

AU - Jia, Chao Xiang

AU - Spotnitz, Henry M.

PY - 1997/5

Y1 - 1997/5

N2 - Background. This study compared the adverse effects of crystalloid- induced myocardial edema on left ventricular (LV) compliance in small and large hearts. Methods. Plegisol (289 mOsm/L) was perfused into the coronary arteries of pigs (n = 8) and 1:1 dilute Plegisol (145 mOsm/L) into the coronary arteries of rats (n = 6). Pressure-volume relations, heart weight, and water content were then determined. The pressure-volume relations were compared using an volume at a pressure of 10 mm Hg. Results. Edema in rats was associated with significant (p < 0.05) increases in heart weight (1.1 ± 0.0 g versus 1.4 ± 0.1 g [average ± standard error of the mean]) and water content (76.8% ± 0.4% versus 81.3% ± 0.8%), but an increase in LV stiffness (7.91 ± 0.52 versus 9.27 ± 1.42) and a decrease in the LV volume at 10 mm Hg (0.25 ± 0.02 mL versus 0.14 ± 0.05 mL) were not statistically significant. Edema in pigs was associated with statistically significant (p < 0.05) increases in LV stiffness β (0.050 ± 0.004 versus 0.072 ± 0.008), heart weight (207 ± 8 g versus 274 ± 9 g), and water content (79.8% ± 0.6% versus 85.3% ± 0.6%) and a significant decrease in the LV volume at 10 mm Hg (88.4 ± 5.8 mL versus 60.4 ± 6.8 mL). Conclusions. Myocardial edema is associated with an increase in water content and LV stiffness and a decrease in the LV volume at 10 mm Hg in both species. In rats, however, the water content is smaller in the control state and a more hypotonic perfusate is needed to induce a given degree of edema.

AB - Background. This study compared the adverse effects of crystalloid- induced myocardial edema on left ventricular (LV) compliance in small and large hearts. Methods. Plegisol (289 mOsm/L) was perfused into the coronary arteries of pigs (n = 8) and 1:1 dilute Plegisol (145 mOsm/L) into the coronary arteries of rats (n = 6). Pressure-volume relations, heart weight, and water content were then determined. The pressure-volume relations were compared using an volume at a pressure of 10 mm Hg. Results. Edema in rats was associated with significant (p < 0.05) increases in heart weight (1.1 ± 0.0 g versus 1.4 ± 0.1 g [average ± standard error of the mean]) and water content (76.8% ± 0.4% versus 81.3% ± 0.8%), but an increase in LV stiffness (7.91 ± 0.52 versus 9.27 ± 1.42) and a decrease in the LV volume at 10 mm Hg (0.25 ± 0.02 mL versus 0.14 ± 0.05 mL) were not statistically significant. Edema in pigs was associated with statistically significant (p < 0.05) increases in LV stiffness β (0.050 ± 0.004 versus 0.072 ± 0.008), heart weight (207 ± 8 g versus 274 ± 9 g), and water content (79.8% ± 0.6% versus 85.3% ± 0.6%) and a significant decrease in the LV volume at 10 mm Hg (88.4 ± 5.8 mL versus 60.4 ± 6.8 mL). Conclusions. Myocardial edema is associated with an increase in water content and LV stiffness and a decrease in the LV volume at 10 mm Hg in both species. In rats, however, the water content is smaller in the control state and a more hypotonic perfusate is needed to induce a given degree of edema.

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