Myc in stem cell behaviour: Insights from Drosophila

Leonie M. Quinn, Julie Secombe, Gary R. Hime

Research output: Chapter in Book/Report/Conference proceedingChapter

10 Scopus citations

Abstract

The Myc family proteins are key regulators of animal growth and development, which have critical roles in modulating stem cell behaviour. Since the identification of the oncogenic potential of c-Myc in the early 1980s the mammalian Myc family, which is comprised of c-Myc, N-Myc, and L-Myc, has been studied extensively. dMyc, the only Drosophila member of the Myc gene family, is orthologous to the mammalian c-Myc oncoprotein. Here we discuss key studies addressing the function of the Myc family in stem cell behaviour in both Drosophila Models and mammalian systems.

Original languageEnglish (US)
Title of host publicationTranscriptional and Translational Regulation of Stem Cells
PublisherSpringer New York LLC
Pages269-285
Number of pages17
ISBN (Print)9789400766204
DOIs
StatePublished - Jan 1 2013

Publication series

NameAdvances in Experimental Medicine and Biology
Volume786
ISSN (Print)0065-2598

Keywords

  • Cancer
  • Cell cycle
  • Cell growth
  • Drosophila
  • Myc
  • Stem cells

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Quinn, L. M., Secombe, J., & Hime, G. R. (2013). Myc in stem cell behaviour: Insights from Drosophila. In Transcriptional and Translational Regulation of Stem Cells (pp. 269-285). (Advances in Experimental Medicine and Biology; Vol. 786). Springer New York LLC. https://doi.org/10.1007/978-94-7-6621-1_15