Myc in stem cell behaviour: Insights from Drosophila

Leonie M. Quinn, Julie Secombe, Gary R. Hime

Research output: Chapter in Book/Report/Conference proceedingChapter

10 Citations (Scopus)

Abstract

The Myc family proteins are key regulators of animal growth and development, which have critical roles in modulating stem cell behaviour. Since the identification of the oncogenic potential of c-Myc in the early 1980s the mammalian Myc family, which is comprised of c-Myc, N-Myc, and L-Myc, has been studied extensively. dMyc, the only Drosophila member of the Myc gene family, is orthologous to the mammalian c-Myc oncoprotein. Here we discuss key studies addressing the function of the Myc family in stem cell behaviour in both Drosophila Models and mammalian systems.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages269-285
Number of pages17
Volume786
ISBN (Print)9789400766204
DOIs
StatePublished - 2013

Publication series

NameAdvances in Experimental Medicine and Biology
Volume786
ISSN (Print)00652598

Fingerprint

Stem cells
Drosophila
Stem Cells
myc Genes
Oncogene Proteins
Growth and Development
Animals
Genes
Proteins

Keywords

  • Cancer
  • Cell cycle
  • Cell growth
  • Drosophila
  • Myc
  • Stem cells

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Quinn, L. M., Secombe, J., & Hime, G. R. (2013). Myc in stem cell behaviour: Insights from Drosophila. In Advances in Experimental Medicine and Biology (Vol. 786, pp. 269-285). (Advances in Experimental Medicine and Biology; Vol. 786). Springer New York LLC. https://doi.org/10.1007/978-94-7-6621-1_15

Myc in stem cell behaviour : Insights from Drosophila. / Quinn, Leonie M.; Secombe, Julie; Hime, Gary R.

Advances in Experimental Medicine and Biology. Vol. 786 Springer New York LLC, 2013. p. 269-285 (Advances in Experimental Medicine and Biology; Vol. 786).

Research output: Chapter in Book/Report/Conference proceedingChapter

Quinn, LM, Secombe, J & Hime, GR 2013, Myc in stem cell behaviour: Insights from Drosophila. in Advances in Experimental Medicine and Biology. vol. 786, Advances in Experimental Medicine and Biology, vol. 786, Springer New York LLC, pp. 269-285. https://doi.org/10.1007/978-94-7-6621-1_15
Quinn LM, Secombe J, Hime GR. Myc in stem cell behaviour: Insights from Drosophila. In Advances in Experimental Medicine and Biology. Vol. 786. Springer New York LLC. 2013. p. 269-285. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-94-7-6621-1_15
Quinn, Leonie M. ; Secombe, Julie ; Hime, Gary R. / Myc in stem cell behaviour : Insights from Drosophila. Advances in Experimental Medicine and Biology. Vol. 786 Springer New York LLC, 2013. pp. 269-285 (Advances in Experimental Medicine and Biology).
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