Muscularity in adult humans: Proportion of adipose tissue-free body mass as skeletal muscle

Zimian Wang, Moonseong Heo, Robert C. Lee, Donald P. Kotler, Robert T. Withers, Steven B. Heymsfield

Research output: Contribution to journalArticle

57 Scopus citations

Abstract

Muscularity, or the proportion of adipose tissue-free body mass (ATFM) as skeletal muscle (SM), provides valuable body composition information, especially for age-related SM loss (i.e., sarcopenia). Limited data from elderly cadavers suggest a relatively constant SM/ATFM ratio, 0.540 ± 0.046 for men (mean ± SD, n = 6) and 0.489 ± 0.049 for women (n = 7). The aim of the present study was to examine the magnitude and constancy of the SM/ATFM ratio in healthy adults. Whole-body SM and ATFM were measured using multi-scan magnetic resonance imaging. The SM/ATFM ratio was 0.528 ± 0.036 for men (n = 139) and 0.473 ± 0.037 for women (n = 165). Multiple regression analysis indicated that the SM/ATFM ratio was significantly influenced by sex, age, body weight, and race. The four factors explained 50% of the observed between individual variation in the SM/ATFM ratio. After adjusting for age, body weight, and race, men had a larger SM/ATFM ratio than women. Both older men and women had a lower SM/ATFM ratio than younger subjects, although the relative reduction was greater in men. After adjustment for sex, age, and body weight, there were no significant differences in the SM/ATFM ratios between Asian, Caucasian, and Hispanic subjects. In contrast, African-American subjects had a significantly greater SM/ATFM ratio than subjects in the other three groups. In addition, the SM/ATFM ratio was significantly lower in AIDS patients than corresponding values in healthy subjects.

Original languageEnglish (US)
Pages (from-to)612-619
Number of pages8
JournalAmerican Journal of Human Biology
Volume13
Issue number5
DOIs
StatePublished - Sep 1 2001

ASJC Scopus subject areas

  • Anatomy
  • Ecology, Evolution, Behavior and Systematics
  • Anthropology
  • Genetics

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    Wang, Z., Heo, M., Lee, R. C., Kotler, D. P., Withers, R. T., & Heymsfield, S. B. (2001). Muscularity in adult humans: Proportion of adipose tissue-free body mass as skeletal muscle. American Journal of Human Biology, 13(5), 612-619. https://doi.org/10.1002/ajhb.1099