Multimodal MRI of Nonhuman Primate Stroke

Hsiao Ying Wey, Timothy Q. Duong

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Stroke is the fourth leading cause of death. Despite decades of research, no neuroprotective drug has proven to be effective clinically. One widely accepted view to account for this negative outcome is that the rodent stroke model simply does not adequately reflect the complexity of human stroke. Recent failures of several high-profile neuroprotective drugs for stroke treatment in phase III clinical trials further underscore the importance of developing adequate animal models for stroke research. The brain organization and vascular circuitry of nonhuman primates (NHPs) are more homologous with humans than the widely used rodent for stroke modeling. The Stroke Therapy Academic Industry Roundtable, a national committee commissioned by the American Heart Association, recommended that clinically relevant NHP stroke models be established for developing and assessing neuroprotective drugs. The aim of this article is to review the challenges and applications of magnetic resonance imaging studies of NHP stroke models.

Original languageEnglish (US)
Pages (from-to)84-89
Number of pages6
JournalTranslational Stroke Research
Volume3
Issue number1
DOIs
StatePublished - Mar 2012
Externally publishedYes

Keywords

  • Diffusion
  • Functional MRI
  • MCAO
  • MRI
  • Nonhuman primate
  • Perfusion

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Multimodal MRI of Nonhuman Primate Stroke'. Together they form a unique fingerprint.

Cite this