Multidrug resistance gene expression is controlled by steroid hormones in the secretory epithelium of the uterus

R. J. Arceci, F. Baas, R. Raponi, Susan Band Horwitz, D. Housman, J. M. Croop

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

The multidrug resistance (mdr) gene family has been shown to encode a membrane glycoprotein, termed the P-glycoprotein, which functions as a drug efflux pump with broad substrate specificity. This multigene family is expressed in a tissue-specific fashion in a wide variety of normal and neoplastic tissues. The regulation of mdr gene expression in normal tissues is not understood. We have recently shown that mdr mRNA and the P-glycoprotein increases dramatically in the secretory luminal and glandular epithelium of the gravid murine uterus. This observation has suggested that mdr gene expression in the uterus is controlled by the physiologic changes associated with pregnancy. This report now demonstrates that mdr mRNA and P-glycoprotein are induced at high levels in the uterine secretory epithelium by the combination of estrogen and progesterone, the major steroid hormones of pregnancy. This regulation of mdr gene expression in the uterus does not require any other contribution from the fetus or placenta. The data indicate that this gene locus is hormonally responsive to estrogen and progesterone in the uterine secretory epithelium, suggesting an important and physiologically regulated role during pregnancy.

Original languageEnglish (US)
Pages (from-to)101-109
Number of pages9
JournalMolecular Reproduction and Development
Volume25
Issue number2
StatePublished - 1990

Fingerprint

MDR Genes
Uterus
P-Glycoprotein
Epithelium
Steroids
Hormones
Gene Expression
Multiple Drug Resistance
Pregnancy
Progesterone
Estrogens
Messenger RNA
Membrane Glycoproteins
Multigene Family
Substrate Specificity
Placenta
Fetus
Pharmaceutical Preparations
Genes

Keywords

  • development
  • in situ hybridization
  • mdr gene
  • pregnancy

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology
  • Cell Biology

Cite this

Multidrug resistance gene expression is controlled by steroid hormones in the secretory epithelium of the uterus. / Arceci, R. J.; Baas, F.; Raponi, R.; Band Horwitz, Susan; Housman, D.; Croop, J. M.

In: Molecular Reproduction and Development, Vol. 25, No. 2, 1990, p. 101-109.

Research output: Contribution to journalArticle

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