Multicomponent reaction through cooperative trio catalysis incorporating enamine, Brønsted acid and metal Lewis acid catalysis: A concise route to access chromans

Chamini V. Karunaratne, Ryan G. Sarkisian, Jennifer Reeves, Yongming Deng, Kraig A. Wheeler, Hong Wang

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

An atom-economical multicomponent cascade reaction of salicylaldehydes, cyclohexanones and arylamines has been developed for the synthesis of three-ring fused chromans. This reaction was achieved through cooperative enamine-metal Lewis acid assisted Brønsted acid catalysis, furnishing the products in excellent yields with good diastereoselectivity.

Original languageEnglish (US)
Pages (from-to)4933-4936
Number of pages4
JournalOrganic and Biomolecular Chemistry
Volume15
Issue number23
DOIs
StatePublished - 2017

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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