An atom-economical multicomponent cascade reaction of salicylaldehydes, cyclohexanones and arylamines has been developed for the synthesis of three-ring fused chromans. This reaction was achieved through cooperative enamine-metal Lewis acid assisted Brønsted acid catalysis, furnishing the products in excellent yields with good diastereoselectivity.
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry
Multicomponent reaction through cooperative trio catalysis incorporating enamine, Brønsted acid and metal Lewis acid catalysis : A concise route to access chromans. / Karunaratne, Chamini V.; Sarkisian, Ryan G.; Reeves, Jennifer; Deng, Yongming; Wheeler, Kraig A.; Wang, Hong.In: Organic and Biomolecular Chemistry, Vol. 15, No. 23, 01.01.2017, p. 4933-4936.
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