Multi-modal label-free imaging based on a femtosecond fiber laser

Ruxin Xie, Jue Su, Eric C. Rentchler, Ziyan Zhang, Carey K. Johnson, Honglian Shi, Rongqing Hui

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

We demonstrate multi-mode microscopy based on a single femtosecond fiber laser. Coherent anti-Stokes Raman scattering (CARS), stimulated Raman scattering (SRS) and photothermal images can be obtained simultaneously with this simplified setup. Distributions of lipid and hemoglobin in sliced mouse brain samples and blood cells are imaged. The dependency of signal amplitude on the pump power and pump modulation frequency is characterized, which allows to isolate the impact from different contributions.

Original languageEnglish (US)
Pages (from-to)2390-2396
Number of pages7
JournalBiomedical Optics Express
Volume5
Issue number7
DOIs
StatePublished - Jun 1 2014
Externally publishedYes

ASJC Scopus subject areas

  • Biotechnology
  • Atomic and Molecular Physics, and Optics

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  • Cite this

    Xie, R., Su, J., Rentchler, E. C., Zhang, Z., Johnson, C. K., Shi, H., & Hui, R. (2014). Multi-modal label-free imaging based on a femtosecond fiber laser. Biomedical Optics Express, 5(7), 2390-2396. https://doi.org/10.1364/BOE.5.002390