Multi-modal label-free imaging based on a femtosecond fiber laser

Ruxin Xie; Jue Su; Eric C. Rentchler; Ziyan Zhang; Carey K. Johnson; Honglian Shi; Rongqing Hui

doi:10.1364/BOE.5.002390

Multi-modal label-free imaging based on a femtosecond fiber laser

Ruxin Xie, Jue Su, Eric C. Rentchler, Ziyan Zhang, Carey K. Johnson, Honglian Shi, Rongqing Hui

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

We demonstrate multi-mode microscopy based on a single femtosecond fiber laser. Coherent anti-Stokes Raman scattering (CARS), stimulated Raman scattering (SRS) and photothermal images can be obtained simultaneously with this simplified setup. Distributions of lipid and hemoglobin in sliced mouse brain samples and blood cells are imaged. The dependency of signal amplitude on the pump power and pump modulation frequency is characterized, which allows to isolate the impact from different contributions.

Original language	English (US)
Pages (from-to)	2390-2396
Number of pages	7
Journal	Biomedical Optics Express
Volume	5
Issue number	7
DOIs	https://doi.org/10.1364/BOE.5.002390
State	Published - Jun 1 2014
Externally published	Yes

ASJC Scopus subject areas

Biotechnology
Atomic and Molecular Physics, and Optics

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AU - Su, Jue

AU - Rentchler, Eric C.

AU - Zhang, Ziyan

AU - Johnson, Carey K.

AU - Shi, Honglian

AU - Hui, Rongqing

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AB - We demonstrate multi-mode microscopy based on a single femtosecond fiber laser. Coherent anti-Stokes Raman scattering (CARS), stimulated Raman scattering (SRS) and photothermal images can be obtained simultaneously with this simplified setup. Distributions of lipid and hemoglobin in sliced mouse brain samples and blood cells are imaged. The dependency of signal amplitude on the pump power and pump modulation frequency is characterized, which allows to isolate the impact from different contributions.

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Multi-modal label-free imaging based on a femtosecond fiber laser

Abstract

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