Mucosal escherichia coli bactericidal activity and immune mediators are associated with HIV-1 seroconversion in women participating in the HPTN 035 trial

Charlene S. Dezzutti, Barbra A. Richardson, Jeanne M. Marrazzo, Jessica Tugetman, Gita Ramjee, Taha Taha, Zvavahera M. Chirenje, Salim S. Abdool Karim, Sharon L. Hillier, Betsy C. Herold

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

The mucosal environment may impact the risk for human immunodeficiency virus type 1 (HIV-1) acquisition. Immune mediators were measured in vaginal fluid collected from HPTN 035 participants who acquired HIV-1 and from those who remained HIV-1 negative (controls). Mediator concentrations were similar in samples obtained before as compared to after HIV-1 acquisition in the 8 seroconverters. Compared with controls, seroconverters were more likely to have detectable levels of HD-2 (odds ratio [OR], 2.39; P =. 005) and greater Escherichia coli bactericidal activity (OR, 1.22; P =. 01) prior to seroconversion. E. coli bactericidal activity remained significant in a multivariable analysis (P =. 02) and may be a biomarker for HIV-1 acquisition.

Original languageEnglish (US)
Pages (from-to)1931-1935
Number of pages5
JournalJournal of Infectious Diseases
Volume206
Issue number12
DOIs
StatePublished - Dec 15 2012

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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    Dezzutti, C. S., Richardson, B. A., Marrazzo, J. M., Tugetman, J., Ramjee, G., Taha, T., Chirenje, Z. M., Abdool Karim, S. S., Hillier, S. L., & Herold, B. C. (2012). Mucosal escherichia coli bactericidal activity and immune mediators are associated with HIV-1 seroconversion in women participating in the HPTN 035 trial. Journal of Infectious Diseases, 206(12), 1931-1935. https://doi.org/10.1093/infdis/jis555