mTORC1 in AGRP neurons integrates exteroceptive and interoceptive food-related cues in the modulation of adaptive energy expenditure in mice

Luke K. Burke, Tamana Darwish, Althea R. Cavanaugh, Sam Virtue, Emma Roth, Joanna Morro, Shun Mei Liu, Jing Xia, Jeffrey W. Dalley, Keith Burling, Streamson C. Chua, Jr., Toni Vidal-Puig, Gary J. Schwartz, Clémence Blouet

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Energy dissipation through interscapular brown adipose tissue (iBAT) thermogenesis is an important contributor to adaptive energy expenditure. However, it remains unresolved how acute and chronic changes in energy availability are detected by the brain to adjust iBAT activity and maintain energy homeostasis. Here, we provide evidence that AGRP inhibitory tone to iBAT represents an energy-sparing circuit that integrates environmental food cues and internal signals of energy availability. We establish a role for the nutrient-sensing mTORC1 signaling pathway within AGRP neurons in the detection of environmental food cues and internal signals of energy availability, and in the bi-directional control of iBAT thermogenesis during nutrient deficiency and excess. Collectively, our findings provide insights into how mTORC1 signaling within AGRP neurons surveys energy availability to engage iBAT thermogenesis, and identify AGRP neurons as a neuronal substrate for the coordination of energy intake and adaptive expenditure under varying physiological and environmental contexts.

Original languageEnglish (US)
Article numbere22848
JournaleLife
Volume6
DOIs
StatePublished - May 23 2017

Fingerprint

Brown Adipose Tissue
Energy Metabolism
Neurons
Cues
Modulation
Tissue
Thermogenesis
Food
Availability
Nutrients
Health Expenditures
Energy Intake
Brain
Energy dissipation
Homeostasis
mechanistic target of rapamycin complex 1
Networks (circuits)
Substrates

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)
  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

mTORC1 in AGRP neurons integrates exteroceptive and interoceptive food-related cues in the modulation of adaptive energy expenditure in mice. / Burke, Luke K.; Darwish, Tamana; Cavanaugh, Althea R.; Virtue, Sam; Roth, Emma; Morro, Joanna; Liu, Shun Mei; Xia, Jing; Dalley, Jeffrey W.; Burling, Keith; Chua, Jr., Streamson C.; Vidal-Puig, Toni; Schwartz, Gary J.; Blouet, Clémence.

In: eLife, Vol. 6, e22848, 23.05.2017.

Research output: Contribution to journalArticle

Burke, LK, Darwish, T, Cavanaugh, AR, Virtue, S, Roth, E, Morro, J, Liu, SM, Xia, J, Dalley, JW, Burling, K, Chua, Jr., SC, Vidal-Puig, T, Schwartz, GJ & Blouet, C 2017, 'mTORC1 in AGRP neurons integrates exteroceptive and interoceptive food-related cues in the modulation of adaptive energy expenditure in mice', eLife, vol. 6, e22848. https://doi.org/10.7554/eLife.22848
Burke, Luke K. ; Darwish, Tamana ; Cavanaugh, Althea R. ; Virtue, Sam ; Roth, Emma ; Morro, Joanna ; Liu, Shun Mei ; Xia, Jing ; Dalley, Jeffrey W. ; Burling, Keith ; Chua, Jr., Streamson C. ; Vidal-Puig, Toni ; Schwartz, Gary J. ; Blouet, Clémence. / mTORC1 in AGRP neurons integrates exteroceptive and interoceptive food-related cues in the modulation of adaptive energy expenditure in mice. In: eLife. 2017 ; Vol. 6.
@article{d1e76ba990634609a7275f3bc7502e1e,
title = "mTORC1 in AGRP neurons integrates exteroceptive and interoceptive food-related cues in the modulation of adaptive energy expenditure in mice",
abstract = "Energy dissipation through interscapular brown adipose tissue (iBAT) thermogenesis is an important contributor to adaptive energy expenditure. However, it remains unresolved how acute and chronic changes in energy availability are detected by the brain to adjust iBAT activity and maintain energy homeostasis. Here, we provide evidence that AGRP inhibitory tone to iBAT represents an energy-sparing circuit that integrates environmental food cues and internal signals of energy availability. We establish a role for the nutrient-sensing mTORC1 signaling pathway within AGRP neurons in the detection of environmental food cues and internal signals of energy availability, and in the bi-directional control of iBAT thermogenesis during nutrient deficiency and excess. Collectively, our findings provide insights into how mTORC1 signaling within AGRP neurons surveys energy availability to engage iBAT thermogenesis, and identify AGRP neurons as a neuronal substrate for the coordination of energy intake and adaptive expenditure under varying physiological and environmental contexts.",
author = "Burke, {Luke K.} and Tamana Darwish and Cavanaugh, {Althea R.} and Sam Virtue and Emma Roth and Joanna Morro and Liu, {Shun Mei} and Jing Xia and Dalley, {Jeffrey W.} and Keith Burling and {Chua, Jr.}, {Streamson C.} and Toni Vidal-Puig and Schwartz, {Gary J.} and Cl{\'e}mence Blouet",
year = "2017",
month = "5",
day = "23",
doi = "10.7554/eLife.22848",
language = "English (US)",
volume = "6",
journal = "eLife",
issn = "2050-084X",
publisher = "eLife Sciences Publications",

}

TY - JOUR

T1 - mTORC1 in AGRP neurons integrates exteroceptive and interoceptive food-related cues in the modulation of adaptive energy expenditure in mice

AU - Burke, Luke K.

AU - Darwish, Tamana

AU - Cavanaugh, Althea R.

AU - Virtue, Sam

AU - Roth, Emma

AU - Morro, Joanna

AU - Liu, Shun Mei

AU - Xia, Jing

AU - Dalley, Jeffrey W.

AU - Burling, Keith

AU - Chua, Jr., Streamson C.

AU - Vidal-Puig, Toni

AU - Schwartz, Gary J.

AU - Blouet, Clémence

PY - 2017/5/23

Y1 - 2017/5/23

N2 - Energy dissipation through interscapular brown adipose tissue (iBAT) thermogenesis is an important contributor to adaptive energy expenditure. However, it remains unresolved how acute and chronic changes in energy availability are detected by the brain to adjust iBAT activity and maintain energy homeostasis. Here, we provide evidence that AGRP inhibitory tone to iBAT represents an energy-sparing circuit that integrates environmental food cues and internal signals of energy availability. We establish a role for the nutrient-sensing mTORC1 signaling pathway within AGRP neurons in the detection of environmental food cues and internal signals of energy availability, and in the bi-directional control of iBAT thermogenesis during nutrient deficiency and excess. Collectively, our findings provide insights into how mTORC1 signaling within AGRP neurons surveys energy availability to engage iBAT thermogenesis, and identify AGRP neurons as a neuronal substrate for the coordination of energy intake and adaptive expenditure under varying physiological and environmental contexts.

AB - Energy dissipation through interscapular brown adipose tissue (iBAT) thermogenesis is an important contributor to adaptive energy expenditure. However, it remains unresolved how acute and chronic changes in energy availability are detected by the brain to adjust iBAT activity and maintain energy homeostasis. Here, we provide evidence that AGRP inhibitory tone to iBAT represents an energy-sparing circuit that integrates environmental food cues and internal signals of energy availability. We establish a role for the nutrient-sensing mTORC1 signaling pathway within AGRP neurons in the detection of environmental food cues and internal signals of energy availability, and in the bi-directional control of iBAT thermogenesis during nutrient deficiency and excess. Collectively, our findings provide insights into how mTORC1 signaling within AGRP neurons surveys energy availability to engage iBAT thermogenesis, and identify AGRP neurons as a neuronal substrate for the coordination of energy intake and adaptive expenditure under varying physiological and environmental contexts.

UR - http://www.scopus.com/inward/record.url?scp=85019751108&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85019751108&partnerID=8YFLogxK

U2 - 10.7554/eLife.22848

DO - 10.7554/eLife.22848

M3 - Article

VL - 6

JO - eLife

JF - eLife

SN - 2050-084X

M1 - e22848

ER -