MSC niche for hematopoiesis

Daniel Lucas; Sandra Pinho; Paul S. Frenette

doi:10.1007/978-1-4614-5711-4_6

MSC niche for hematopoiesis

Daniel Lucas, Sandra Pinho, Paul S. Frenette

Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Blood cell production is maintained throughout life by hematopoietic stem cells (HSC), which reside in specific areas of the bone marrow (BM) referred to as niches. These niches regulate the self-renewal, proliferation, and migration of HSC and also integrate signals from the periphery to respond to the hematopoietic demand. In the last decade, several putative cellular components of the HSC niche have been identified. Here, we briefly review current knowledge on different putative niche cells and their regulation.

Original language	English (US)
Title of host publication	Mesenchymal Stromal Cells
Subtitle of host publication	Biology and Clinical Applications
Publisher	Springer New York
Pages	91-106
Number of pages	16
ISBN (Electronic)	9781461457114
ISBN (Print)	9781461457107
DOIs	https://doi.org/10.1007/978-1-4614-5711-4_6
State	Published - Jan 1 2013

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1007/978-1-4614-5711-4_6

Cite this

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MSC niche for hematopoiesis

Abstract

ASJC Scopus subject areas

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