Mouse Models of Colon Cancer

Makoto Mark Taketo, Winfried Edelmann

Research output: Contribution to journalArticle

159 Citations (Scopus)

Abstract

Genetically engineered mice are essential tools in both mechanistic studies and drug development in colon cancer research. Mice with mutations in the Apc gene, as well as in genes that modify or interact with Apc, are important models of familial adenomatous polyposis. Mice with mutations in the β-catenin signaling pathway have also revealed important information about colon cancer pathogenesis, along with models for hereditary nonpolyposis colon cancer and inflammatory bowel diseases associated with colon cancer. Finally, transplantation models (xenografts) have been useful in the study of metastasis and for testing potential therapeutics. This review discusses what models have been developed most recently and what they have taught us about colon cancer formation, progression, and possible treatment strategies.

Original languageEnglish (US)
Pages (from-to)780-798
Number of pages19
JournalGastroenterology
Volume136
Issue number3
DOIs
StatePublished - Mar 2009

Fingerprint

Colonic Neoplasms
Hereditary Nonpolyposis Colorectal Neoplasms
Catenins
Heterologous Transplantation
Mutation
Adenomatous Polyposis Coli
Inflammatory Bowel Diseases
Genes
Neoplasm Metastasis
Research
Pharmaceutical Preparations
Therapeutics

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Mouse Models of Colon Cancer. / Taketo, Makoto Mark; Edelmann, Winfried.

In: Gastroenterology, Vol. 136, No. 3, 03.2009, p. 780-798.

Research output: Contribution to journalArticle

Taketo, Makoto Mark ; Edelmann, Winfried. / Mouse Models of Colon Cancer. In: Gastroenterology. 2009 ; Vol. 136, No. 3. pp. 780-798.
@article{b76f1e3412d545b7a63e78e5357a8439,
title = "Mouse Models of Colon Cancer",
abstract = "Genetically engineered mice are essential tools in both mechanistic studies and drug development in colon cancer research. Mice with mutations in the Apc gene, as well as in genes that modify or interact with Apc, are important models of familial adenomatous polyposis. Mice with mutations in the β-catenin signaling pathway have also revealed important information about colon cancer pathogenesis, along with models for hereditary nonpolyposis colon cancer and inflammatory bowel diseases associated with colon cancer. Finally, transplantation models (xenografts) have been useful in the study of metastasis and for testing potential therapeutics. This review discusses what models have been developed most recently and what they have taught us about colon cancer formation, progression, and possible treatment strategies.",
author = "Taketo, {Makoto Mark} and Winfried Edelmann",
year = "2009",
month = "3",
doi = "10.1053/j.gastro.2008.12.049",
language = "English (US)",
volume = "136",
pages = "780--798",
journal = "Gastroenterology",
issn = "0016-5085",
publisher = "W.B. Saunders Ltd",
number = "3",

}

TY - JOUR

T1 - Mouse Models of Colon Cancer

AU - Taketo, Makoto Mark

AU - Edelmann, Winfried

PY - 2009/3

Y1 - 2009/3

N2 - Genetically engineered mice are essential tools in both mechanistic studies and drug development in colon cancer research. Mice with mutations in the Apc gene, as well as in genes that modify or interact with Apc, are important models of familial adenomatous polyposis. Mice with mutations in the β-catenin signaling pathway have also revealed important information about colon cancer pathogenesis, along with models for hereditary nonpolyposis colon cancer and inflammatory bowel diseases associated with colon cancer. Finally, transplantation models (xenografts) have been useful in the study of metastasis and for testing potential therapeutics. This review discusses what models have been developed most recently and what they have taught us about colon cancer formation, progression, and possible treatment strategies.

AB - Genetically engineered mice are essential tools in both mechanistic studies and drug development in colon cancer research. Mice with mutations in the Apc gene, as well as in genes that modify or interact with Apc, are important models of familial adenomatous polyposis. Mice with mutations in the β-catenin signaling pathway have also revealed important information about colon cancer pathogenesis, along with models for hereditary nonpolyposis colon cancer and inflammatory bowel diseases associated with colon cancer. Finally, transplantation models (xenografts) have been useful in the study of metastasis and for testing potential therapeutics. This review discusses what models have been developed most recently and what they have taught us about colon cancer formation, progression, and possible treatment strategies.

UR - http://www.scopus.com/inward/record.url?scp=60449086469&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=60449086469&partnerID=8YFLogxK

U2 - 10.1053/j.gastro.2008.12.049

DO - 10.1053/j.gastro.2008.12.049

M3 - Article

C2 - 19263594

AN - SCOPUS:60449086469

VL - 136

SP - 780

EP - 798

JO - Gastroenterology

JF - Gastroenterology

SN - 0016-5085

IS - 3

ER -