Morphologic pattern of tenascin as a diagnostic biomarker in colon cancer

Basem F. Iskaros, Kathryn E. Tanaka, Xiaoping Hu, Anna S. Kadish, Jacob J. Steinberg

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

Background: Immunohistochemical methods were used to study the pattern of expression of tenascin (TN) in invasive colon cancer and its relation to prognosis. Methods: Sixty patients (29 males, 31 females) with a mean age of 77 years were studied. TN expression was evaluated by immunohistochemistry using paraffin-embedded tissue sections, TN expression levels were correlated with patient age, tumor stage, and survival. Results: TN positivity varied from trace to 4+. Staining patterns were as follows: in well-differentiated cancer, TN fibers form thick bands around invading tumor glands. In poorly differentiated cancer, TN fibers had an interstitial pattern surrounding individual tumor cells. Using Cox's proportional hazard regression method, survival was significantly related to TN score (P < 0.0001) and stage of disease (P < 0.05). No significant relationship was found between survival and age (P = 0.375). Conclusion: Patients with more TN expression had better long-term survival than patients with no or weak TN expression. Pathologic and clinical entities in colon cancer have distinct immunohistochemical TN matrix patterns that may correlate with predictive value and long-term survival.

Original languageEnglish (US)
Pages (from-to)98-101
Number of pages4
JournalJournal of Surgical Oncology
Volume64
Issue number2
DOIs
Publication statusPublished - Feb 1 1997

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Keywords

  • adhesion molecule
  • extracellular matrix
  • glycoprotein

ASJC Scopus subject areas

  • Surgery
  • Oncology

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