Monoamines and abnormal behaviour. A multi-aminergic perspective

H. M. Van Praag, G. M. Asnis, R. S. Khan, S. L. Brown, M. Korn, J. M. Harkavy Friedman, Scott Wetzler

Research output: Contribution to journalArticle

154 Citations (Scopus)

Abstract

Classical nosology has been the cornerstone of biological psychiatric research; finding biological markers and eventually causes of diseases entities has been the major goal. Another approach, designated as 'functional', is advanced here, attempting to correlate biological variables with psychological dysfunctions, the latter being considered to be the basic units of classification in psychopathology. Signs of diminished DA, 5-HT and NA metabolism, as have been found in psychiatric disorders, are not disorder-specific, but rather are related to psychopathological dimensions (hypoactivity/inertia, increased aggression/anxiety, and anhedonia) independent of the nosological framework in which these dysfunctions occur. Implications of the functional approach for psychiatry include a shift from nosological to functional application of psychotropic drugs. Functional psychopharmacology will be dysfuntion-orientated and therefore geared towards utilising drug combinations. This prospect is hailed as progress, both practically and scientifically.

Original languageEnglish (US)
Pages (from-to)723-734
Number of pages12
JournalBritish Journal of Psychiatry
Volume157
Issue numberNOV.
StatePublished - 1990

Fingerprint

Psychiatry
Biological Psychiatry
Anhedonia
Psychopharmacology
Psychotropic Drugs
Drug Combinations
Aggression
Psychopathology
Serotonin
Anxiety
Biomarkers
Psychology
Research

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuroscience(all)

Cite this

Van Praag, H. M., Asnis, G. M., Khan, R. S., Brown, S. L., Korn, M., Harkavy Friedman, J. M., & Wetzler, S. (1990). Monoamines and abnormal behaviour. A multi-aminergic perspective. British Journal of Psychiatry, 157(NOV.), 723-734.

Monoamines and abnormal behaviour. A multi-aminergic perspective. / Van Praag, H. M.; Asnis, G. M.; Khan, R. S.; Brown, S. L.; Korn, M.; Harkavy Friedman, J. M.; Wetzler, Scott.

In: British Journal of Psychiatry, Vol. 157, No. NOV., 1990, p. 723-734.

Research output: Contribution to journalArticle

Van Praag, HM, Asnis, GM, Khan, RS, Brown, SL, Korn, M, Harkavy Friedman, JM & Wetzler, S 1990, 'Monoamines and abnormal behaviour. A multi-aminergic perspective', British Journal of Psychiatry, vol. 157, no. NOV., pp. 723-734.
Van Praag HM, Asnis GM, Khan RS, Brown SL, Korn M, Harkavy Friedman JM et al. Monoamines and abnormal behaviour. A multi-aminergic perspective. British Journal of Psychiatry. 1990;157(NOV.):723-734.
Van Praag, H. M. ; Asnis, G. M. ; Khan, R. S. ; Brown, S. L. ; Korn, M. ; Harkavy Friedman, J. M. ; Wetzler, Scott. / Monoamines and abnormal behaviour. A multi-aminergic perspective. In: British Journal of Psychiatry. 1990 ; Vol. 157, No. NOV. pp. 723-734.
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