Monitoring of blood vessels and tissues by a population of monocytes with patrolling behavior

Cedric Auffray, Darin Fogg, Meriem Garfa, Gaelle Elain, Olivier Join-Lambert, Samer Kayal, Sabine Sarnacki, Ana Cumano, Gregoire Lauvau, Frederic Geissmann

Research output: Contribution to journalArticle

1064 Citations (Scopus)

Abstract

The cellular immune response to tissue damage and infection requires the recruitment of blood leukocytes. This process is mediated through a classical multistep mechanism, which involves transient rolling on the endothelium and recognition of inflammation followed by extravasation. We have shown, by direct examination of blood monocyte functions in vivo, that a subset of monocytes patrols healthy tissues through long-range crawling on the resting endothelium. This patrolling behavior depended on the integrin LFA-1 and the chemokine receptor CX3CR1 and was required for rapid tissue invasion at the site of an infection by this "resident" monocyte population, which initiated an early immune response and differentiated into macrophages.

Original languageEnglish (US)
Pages (from-to)666-670
Number of pages5
JournalScience
Volume317
Issue number5838
DOIs
StatePublished - Aug 3 2007
Externally publishedYes

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Blood Vessels
Monocytes
Endothelium
Population
Lymphocyte Function-Associated Antigen-1
Chemokine Receptors
Infection
Integrins
Cellular Immunity
Leukocytes
Macrophages
Inflammation

ASJC Scopus subject areas

  • General

Cite this

Auffray, C., Fogg, D., Garfa, M., Elain, G., Join-Lambert, O., Kayal, S., ... Geissmann, F. (2007). Monitoring of blood vessels and tissues by a population of monocytes with patrolling behavior. Science, 317(5838), 666-670. https://doi.org/10.1126/science.1142883

Monitoring of blood vessels and tissues by a population of monocytes with patrolling behavior. / Auffray, Cedric; Fogg, Darin; Garfa, Meriem; Elain, Gaelle; Join-Lambert, Olivier; Kayal, Samer; Sarnacki, Sabine; Cumano, Ana; Lauvau, Gregoire; Geissmann, Frederic.

In: Science, Vol. 317, No. 5838, 03.08.2007, p. 666-670.

Research output: Contribution to journalArticle

Auffray, C, Fogg, D, Garfa, M, Elain, G, Join-Lambert, O, Kayal, S, Sarnacki, S, Cumano, A, Lauvau, G & Geissmann, F 2007, 'Monitoring of blood vessels and tissues by a population of monocytes with patrolling behavior', Science, vol. 317, no. 5838, pp. 666-670. https://doi.org/10.1126/science.1142883
Auffray C, Fogg D, Garfa M, Elain G, Join-Lambert O, Kayal S et al. Monitoring of blood vessels and tissues by a population of monocytes with patrolling behavior. Science. 2007 Aug 3;317(5838):666-670. https://doi.org/10.1126/science.1142883
Auffray, Cedric ; Fogg, Darin ; Garfa, Meriem ; Elain, Gaelle ; Join-Lambert, Olivier ; Kayal, Samer ; Sarnacki, Sabine ; Cumano, Ana ; Lauvau, Gregoire ; Geissmann, Frederic. / Monitoring of blood vessels and tissues by a population of monocytes with patrolling behavior. In: Science. 2007 ; Vol. 317, No. 5838. pp. 666-670.
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