Molecular properties of the CRF receptor

Joachim Spiess, Frank M. Dautzenberg, Sabine Sydow, Richard L. Hauger, Andreas Rühmann, Thomas Blank, Jelena Radulovic

Research output: Contribution to journalReview articlepeer-review

40 Scopus citations

Abstract

Research into the biology of corticotropin-releasing factor (CRF) has been intensified significantly by the structural characterization of the CRF receptor (CRF-R). Two receptor subtypes, CRF-R1 and CRF-R2, and three functional splice variants of CRF-R2 have been discovered. It appears that ligand binding requires interaction of the N-terminal domain with one or two other extracellular domains of the CRF-R. In contrast to the mammalian CRF- R1, the frog CRF-R1 discriminates between naturally occurring CRF-like peptides.

Original languageEnglish (US)
Pages (from-to)140-145
Number of pages6
JournalTrends in Endocrinology and Metabolism
Volume9
Issue number4
DOIs
StatePublished - Dec 1 1998
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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